Ye Wen-Yi, Zhao Hong, Ye Jing, Sang Hai-Jin, Zhou Lin-Shui, Lv Jia-Ni, Li Juan-Juan
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.
The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310003, China.
Evid Based Complement Alternat Med. 2023 Feb 7;2023:6483785. doi: 10.1155/2023/6483785. eCollection 2023.
Recently, most scholars have advocated multidisciplinary comprehensive intervention measures for chronic obstructive pulmonary disease (COPD) to improve lung function, relieve symptoms of dyspnea, and improve quality of life. Traditional Chinese medicine (TCM) has rich experience in the treatment of various respiratory system diseases and the rehabilitation of their syndrome differentiation. In this study, total 68 patients with COPD from November 2019 to November 2021 in the hospitals were divided into the control group, ipratropium bromide (IB)-treated group, and IB + TCM-treated group for clinical efficacy observation and to explore the effect of IB combined with TCM on the pulmonary function and psychological status of COPD patients. Patients in the control group were subjected to routine oxygen inhalation, cough and expectorant, and antiviral treatments, while the patients in the IB-treated group were treated with IB and those received in the control group. Patients in the IB + TCM-treated group were treated with IB and TCM intervention. All patients were treated for a month. The results showed that after different interventions, the levels of FEV1, FEV1% pred, FVC, and PEF ( < 0.05) were significantly increased in all the groups, while levels of TNF-, IL-6, IL-8, and CRP in serum as well as Hamilton Anxiety Scale and Hamilton Depression scores were significantly decreased. Compared with the control group and IB-treated group, the IB + TCM-treated group presented the greatest changes on all abovementioned indicators and the lowest total incidence of adverse reactions, indicating the biggest improvement of IB + TCM on the symptoms of COPD patients. Therefore, the combination of IB and TCM intervention effectively improved the pulmonary function and psychological status of COPD patients and could be used as an important adjunct for COPD treatment.
近年来，大多数学者主张对慢性阻塞性肺疾病（COPD）采取多学科综合干预措施，以改善肺功能、缓解呼吸困难症状并提高生活质量。中医在各种呼吸系统疾病的治疗及其辨证康复方面有着丰富经验。本研究将2019年11月至2021年11月期间医院收治的68例COPD患者分为对照组、异丙托溴铵（IB）治疗组和IB联合中医治疗组，进行临床疗效观察，以探讨IB联合中医对COPD患者肺功能和心理状态的影响。对照组患者接受常规吸氧、止咳祛痰及抗病毒治疗，IB治疗组患者在接受对照组治疗的基础上加用IB治疗，IB联合中医治疗组患者在接受IB治疗的基础上进行中医干预。所有患者均治疗1个月。结果显示，经过不同干预后，所有组的第1秒用力呼气容积（FEV1）、FEV1占预计值百分比（FEV1% pred）、用力肺活量（FVC）和呼气峰流速（PEF）水平均显著升高（P＜0.05），而血清中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和C反应蛋白（CRP）水平以及汉密尔顿焦虑量表评分和汉密尔顿抑郁量表评分均显著降低。与对照组和IB治疗组相比，IB联合中医治疗组在上述所有指标上的变化最大，不良反应总发生率最低，表明IB联合中医对COPD患者症状的改善最为显著。因此，IB与中医干预联合应用可有效改善COPD患者的肺功能和心理状态，可作为COPD治疗的重要辅助手段。
