Moeinzadeh Firouzeh, Mortazavi Mojgan, Shahidi Shahrzad, Mansourian Marjan, Yazdani Akram, Zamani Zahra, Seirafian Shiva
Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology and Biostatics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2022 Dec 26;11:112. doi: 10.4103/abr.abr_203_21. eCollection 2022.
To organize efforts to manage the coronavirus disease 2019 (COVID-19), it is necessary to understand which groups are at higher risk of infection. Kidney disease seems to be substantial in COVID-19 patients, but there are limited data on COVID-19 incidence and fatality among chronic kidney disease (CKD) patients. In this study, we intend to examine the association between CKD and susceptibility to COVID-19 infection.
Participants were selected from those recruited in a population-based cross-sectional survey of CKD prevalence and associated risk factors in Iranian people 18 years and older. A three-part questionnaire was used for COVID-19 infection clinical symptoms and epidemiologic and hospitalization data.
A total of 962 individuals including 403 CKD patients and 559 healthy controls were recruited in this study. Healthy controls were suffering more from common cold signs, cough, fever, sore throat, headache, anosmia, dyspnea, and abdominal pain (all < 0.05). Furthermore, the number of healthy individuals with myalgia was marginally higher compared to the CKD patients ( = 0.057). Data regarding the number of CKD patients with/without COVID-19 infection throughout different CKD stages revealed that there was no significant difference between the two groups in terms of COVID-19 infection in different stages of CKD ( = 0.956).
We found that some of the clinical presentations of COVID-19 including common cold symptoms, cough, fever, sore throat, headache, anosmia, dyspnea, and abdominal pain were higher among healthy individuals compared to the CKD group. On the other hand, the susceptibility to COVID-19 infection was not significantly different in various early stages of CKD.
为了组织应对2019冠状病毒病（COVID-19）的工作，有必要了解哪些人群感染风险更高。肾脏疾病在COVID-19患者中似乎很常见，但关于慢性肾脏病（CKD）患者中COVID-19的发病率和死亡率的数据有限。在本研究中，我们旨在研究CKD与COVID-19感染易感性之间的关联。
参与者选自一项基于人群的横断面调查，该调查针对18岁及以上伊朗人群的CKD患病率及相关危险因素。使用一份三部分的问卷收集COVID-19感染的临床症状、流行病学和住院数据。
本研究共招募了962名个体，包括403名CKD患者和559名健康对照。健康对照出现普通感冒症状、咳嗽、发热、咽痛、头痛、嗅觉丧失、呼吸困难和腹痛的情况更多（均P<0.05）。此外，有肌痛的健康个体数量略高于CKD患者（P = 0.057）。关于不同CKD阶段有/无COVID-19感染的CKD患者数量的数据显示，两组在CKD不同阶段的COVID-19感染方面无显著差异（P = 0.956）。
我们发现，与CKD组相比，健康个体中COVID-19的一些临床表现，包括普通感冒症状、咳嗽、发热、咽痛、头痛、嗅觉丧失、呼吸困难和腹痛更为常见。另一方面，CKD各早期阶段对COVID-19感染的易感性无显著差异。
