源自β-酮酸的具有7-酰基的新型头孢菌素。I. 7-（β-酮酰氨基）头孢菌素。
New cephalosporins with 7-acyl groups derived from beta-ketoacids. I. 7-(beta-Ketoacylamino)cephalosporins.
作者信息
Numata M, Yamaoka M, Minamida I, Kuritani M, Imashiro Y
出版信息
J Antibiot (Tokyo). 1978 Dec;31(12):1245-51. doi: 10.7164/antibiotics.31.1245.
PMID:367996
Abstract
The synthesis and antimicrobial profile of a series of 7-(beta-ketoacylamino)cephalosporins (1) bearing an acetoxymethyl or a heterocyclichiomethyl group at the 3-position are described. Of this series, 3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-7-(3-oxobutyrylamino)ceph-3-em-4-carboxylic acid (11) showed moderate antibacterial activities in in vitro and in vivo tests.
摘要
描述了一系列在3位带有乙酰氧甲基或杂环甲基的7-（β-酮酰氨基）头孢菌素（1）的合成及其抗菌谱。在该系列中，3-[[(1-甲基-1H-四氮唑-5-基)硫代]甲基]-7-(3-氧代丁酰氨基)头孢-3-烯-4-羧酸（11）在体外和体内试验中显示出中等抗菌活性。
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