新型头孢菌素和7α-甲氧基头孢菌素。化学与生物活性。
New cephalosporins and 7 alpha-methoxy cephalosporins. Chemistry and biological activities.
作者信息
Elitropi G, Pantò E, Tricerri S, Chiarani L, Pezzali R, Riva M, Zanuso G
出版信息
J Antibiot (Tokyo). 1979 Sep;32(9):900-8. doi: 10.7164/antibiotics.32.900.
PMID:511781
Abstract
The synthesis and the in vitro activity of a number of cephalosporins and 7 alpha-methoxy cephalosporins having 7-acyl substituents derived from 1-methyl-4 (or 5)-nitro-1H-imidazolyl-thioacetic acids are described. The microbiological profile is influenced by the position of both the nitro group and the side-chain sulfur atom on the 1-methyl imidazole, and by the nature of the 3-substituent.
摘要
本文描述了一系列具有源自1-甲基-4（或5）-硝基-1H-咪唑基硫代乙酸的7-酰基取代基的头孢菌素和7α-甲氧基头孢菌素的合成及其体外活性。微生物学特性受1-甲基咪唑上硝基和侧链硫原子的位置以及3-取代基性质的影响。
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