Hooker Jordan P, Parker Bradyn, Wright Elise, Junkers Tanja, Cameron Neil R
Polymer Reaction Design Group, School of Chemistry, Monash University, 19 Rainforest Walk, Clayton, Victoria 3800, Australia.
Department of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia.
ACS Appl Mater Interfaces. 2023 Mar 1;15(8):11141-11149. doi: 10.1021/acsami.2c22546. Epub 2023 Feb 17.
The functionalization of emulsion-templated porous polymers (polyHIPEs) utilizing modern and efficient chemistries is an important avenue for tailoring the properties of these scaffolds for specific and specialized applications. Herein, tetrazole photoclick chemistry is utilized for the efficient functionalization of polyHIPEs synthesized from various monomer systems and polymerization chemistries. Using both radical polymerization and thiol-ene polymerization, polyHIPEs with well-defined, interconnected open-cell morphologies are synthesized with tetrazole concentrations ranging from 0 to 5 w/v %, with the pore diameters ranging from 3 to 24 μm. Analyzed by fluorescence spectroscopy, FTIR spectroscopy, and confocal microscopy, spatially controlled functionalization to generate photopatterned fluorescent polyHIPEs is demonstrated via the reaction with residual acrylate and thiol groups. In addition, the scaffolds can be readily functionalized with external dipolarophiles such as acrylates to incorporate a functionality onto the polyHIPE surface. With many functional tetrazoles also reported in the literature, a PEG-tetrazole is also used to explore the photoinduced functionalization of polyHIPEs possessing tunable ratios of thiol and acrylate groups, and the effect on fluorescence, wettability, and biocompatibility is analyzed. Overall, the reaction is shown to be a broadly applicable tool for polyHIPE functionalization with many avenues for further development toward specific applications.
利用现代高效化学方法对乳液模板化多孔聚合物（聚HIPE）进行功能化，是针对特定和专门应用定制这些支架材料性能的重要途径。在此，四唑光点击化学被用于对由各种单体体系和聚合化学方法合成的聚HIPE进行高效功能化。通过自由基聚合和硫醇-烯聚合，合成了具有明确、相互连接的开孔形态的聚HIPE，四唑浓度范围为0至5 w/v%，孔径范围为3至24μm。通过荧光光谱、傅里叶变换红外光谱和共聚焦显微镜分析，通过与残留的丙烯酸酯和硫醇基团反应，展示了空间控制功能化以生成光图案化荧光聚HIPE。此外，支架可以很容易地用外部亲偶极体如丙烯酸酯进行功能化，以在聚HIPE表面引入一种功能。鉴于文献中也报道了许多功能性四唑，还使用了聚乙二醇-四唑来探索具有可调硫醇和丙烯酸酯基团比例的聚HIPE的光诱导功能化，并分析了其对荧光、润湿性和生物相容性的影响。总体而言，该反应被证明是一种广泛适用的聚HIPE功能化工具，具有许多针对特定应用进一步发展的途径。
