Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.
State Key Laboratory of Transient Optics and Photonics, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.
ACS Appl Mater Interfaces. 2023 Mar 1;15(8):10383-10397. doi: 10.1021/acsami.2c19773. Epub 2023 Feb 17.
In recent years, sunscreens' adverse impacts on the environment and biology have gained wide attention. The improvement of sunscreen safety has become one of the major priorities in skin photoprotection research. It is an effective strategy to develop bionic photoprotective materials by simulating the photoprotective mechanism existing in nature. Inspired by the photoprotective mechanisms of skin and plant leaves, the bionic photoprotective material CS-SA-PDA nanosheet was developed using the free radical grafting method and Michael addition, with natural melanin analogue polydopamine (PDA) nanoparticles and plant sunscreen molecular sinapic acid (SA) as sun protection factors and natural polymer chitosan (CS) as the connecting arm. The results show that CS-SA-PDA can effectively shield UVB and UVA due to the possible synergistic effect between PDA and SA. The introduction of polymer CS significantly improved the photostability of SA and reduced the skin permeability of PDA nanoparticles. The CS-SA-PDA nanosheet can also effectively scavenge photoinduced free radicals. Furthermore, in vivo toxicity and anti-UV evaluations confirm that CS-SA-PDA has no skin irritation and is excellent against skin photodamage, which makes it an ideal skin photoprotective material.
近年来，防晒霜对环境和生物的不良影响引起了广泛关注。提高防晒霜的安全性已成为皮肤光保护研究的主要重点之一。通过模拟自然界中存在的光保护机制来开发仿生光保护材料是一种有效的策略。受皮肤和植物叶片光保护机制的启发，采用自由基接枝法和迈克尔加成法，以天然黑色素类似物聚多巴胺（PDA）纳米粒子和植物防晒分子咖啡酸（SA）为防晒因子，天然聚合物壳聚糖（CS）为连接臂，开发了仿生光保护材料 CS-SA-PDA 纳米片。结果表明，由于 PDA 和 SA 之间可能存在协同作用，CS-SA-PDA 可以有效屏蔽 UVB 和 UVA。聚合物 CS 的引入显著提高了 SA 的光稳定性，并降低了 PDA 纳米粒子的皮肤渗透性。CS-SA-PDA 纳米片还可以有效清除光诱导自由基。此外，体内毒性和抗 UV 评价证实 CS-SA-PDA 无皮肤刺激性，对皮肤光损伤有很好的防护作用，是一种理想的皮肤光保护材料。
