Yasuzawa T, Yoshida M, Shirahata K, Sano H
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
J Antibiot (Tokyo). 1987 Aug;40(8):1111-4. doi: 10.7164/antibiotics.40.1111.
The structure of KS-619-1, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 8,13-dioxo-3-(2-oxopropyl)-5,6,8,13-tetrahydro-1,7,9,11- tetrahydroxybenz[a]naphtacene-2-carboxylic acid by spectral studies of KS-619-1 and its methyl derivative.
通过对KS-619-1及其甲基衍生物的光谱研究，确定强效钙和钙调蛋白依赖性环核苷酸磷酸二酯酶抑制剂KS-619-1的结构为8,13-二氧代-3-(2-氧代丙基)-5,6,8,13-四氢-1,7,9,11-四羟基苯并[a]萘并四烯-2-羧酸。
