Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
AI for Science and Government, The Alan Turing Institute, London NW1 2DB, UK.
Age Ageing. 2023 Feb 1;52(2). doi: 10.1093/ageing/afad018.
Sarcopenia, characterised by an accelerated loss of skeletal muscle mass and function, is associated with negative outcomes. This study aimed to evaluate factors associated with skeletal muscle strength, mass and sarcopenia, particularly protein intake, and to assess whether shared twin characteristics are important.
This study utilised cross-sectional data from a study of community-dwelling twins aged ≥60 years. Multivariable logistic regression and between- and within-twin pair regression modelling were used.
Participants (n = 3,302) were 89% female (n = 2,923), aged a mean of 72.1 (±7.3) years and composed of 858 (55%) monozygotic, 709 (45%) dizygotic twin pairs and 168 individual lone twins. Using optimal protein intake as the reference group (1.0-1.3 g/kg/day), there was no significant association between protein intake (neither high nor low) and low muscle strength, or between low protein intake and sarcopenia (odds ratio (OR) 0.7; 95% confidence interval (CI) 0.39-1.25; P = 0.229) in unadjusted models. High protein intake (>1.3 g/kg/day) was associated with low muscle mass (OR 1.76; 95% CI 1.39-2.24; P < 0.0001), while low protein intake was protective (OR 0.52; 95% CI 0.40-0.67; P < 0.0001). High protein intake was associated with sarcopenia (OR 2.04; 95% CI 1.21-3.44; P = 0.008), and this was robust to adjustment for demographic, anthropometric and dietary factors. The association between muscle strength and weight, body mass index, healthy eating index, protein intake and alpha diversity was not significantly influenced by shared twin factors, indicating greater amenability to interventions.
High protein intake is associated with sarcopenia in a cohort of healthy older twins.
肌少症的特征是骨骼肌质量和功能加速丧失，与不良结局相关。本研究旨在评估与骨骼肌力量、质量和肌少症相关的因素，特别是蛋白质摄入，并评估共享双胞胎特征是否重要。
本研究使用了一项针对年龄≥60 岁的社区居住双胞胎的研究的横断面数据。采用多变量逻辑回归和双胞胎间和双胞胎内回归模型进行分析。
参与者（n=3302）中 89%为女性（n=2923），平均年龄为 72.1（±7.3）岁，包括 858 对（55%）同卵双胞胎、709 对（45%）异卵双胞胎和 168 名单独的个体双胞胎。以最佳蛋白质摄入量作为参考组（1.0-1.3g/kg/天），在未调整模型中，蛋白质摄入量（无论是高还是低）与低肌肉力量之间没有显著关联，低蛋白质摄入量与肌少症之间也没有关联（比值比（OR）0.7；95%置信区间（CI）0.39-1.25；P=0.229）。高蛋白质摄入量（>1.3g/kg/天）与低肌肉质量相关（OR 1.76；95%CI 1.39-2.24；P<0.0001），而低蛋白质摄入量具有保护作用（OR 0.52；95%CI 0.40-0.67；P<0.0001）。高蛋白质摄入量与肌少症相关（OR 2.04；95%CI 1.21-3.44；P=0.008），并且在调整人口统计学、人体测量学和饮食因素后仍然稳健。肌肉力量与体重、体重指数、健康饮食指数、蛋白质摄入和 alpha 多样性之间的关联不受共享双胞胎因素的显著影响，这表明它们更易于干预。
在一组健康的老年双胞胎中，高蛋白质摄入量与肌少症相关。
