Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Brain Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Medicine (Baltimore). 2023 Feb 17;102(7):e33050. doi: 10.1097/MD.0000000000033050.
The purpose was to evaluate the prognostic value of systemic immune-inflammation index (SII) in glioblastoma patients. A total of 100 patients were retrospectively analyzed. We performed Kaplan-Meier and Cox regression analyses to determine the prognostic significance of SII. A nomogram was constructed by incorporating independent prognostic variables. The predictive accuracies of nomograms were evaluated by Harrell concordance index (c-index) and receiver operating characteristic curve analysis; the clinical benefit was evaluated by decision curve analysis. A high SII (>510.8 × 109 cells/L) (hazard ratio = 1.672, P = .034) and neutrophil count (>3.9 × 109 cells/L) (hazard ratio = 1.923, P = .009) were independently related with poor outcome in glioblastoma patients based on Cox analysis. The nomogram incorporating SII showed a good predictive accuracy (c-index = 0.866). Preoperative SII and neutrophil count are potential prognostic biomarkers for overall survival in glioblastoma patients and the nomogram model that integrated the SII may be used to facilitate a comprehensive preoperative survival evaluation.
目的在于评估全身免疫炎症指数（SII）在胶质母细胞瘤患者中的预后价值。回顾性分析了 100 例患者。我们进行了 Kaplan-Meier 和 Cox 回归分析，以确定 SII 的预后意义。通过纳入独立的预后变量来构建列线图。通过 Harrell 一致性指数（c 指数）和接收者操作特征曲线分析评估列线图的预测准确性；通过决策曲线分析评估临床获益。高 SII（>510.8×109 个细胞/L）（风险比=1.672，P=.034）和中性粒细胞计数（>3.9×109 个细胞/L）（风险比=1.923，P=.009）是基于 Cox 分析与胶质母细胞瘤患者不良预后独立相关的因素。纳入 SII 的列线图显示出良好的预测准确性（c 指数=0.866）。术前 SII 和中性粒细胞计数是胶质母细胞瘤患者总生存期的潜在预后生物标志物，整合 SII 的列线图模型可用于促进全面的术前生存评估。
