1990年至2019年期间与溶组织内阿米巴感染相关疾病的全球负担及趋势：一项观察性趋势研究。

Global burden and trends of the Entamoeba infection-associated diseases from 1990 to 2019: An observational trend study.

作者信息

Fu Xiaofang, Zhong Yonghong, Chen Liyan, Ge Minjie, Yu Min, Sun Yibo, Shen Linfeng

机构信息

Linping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Acta Trop. 2023 Apr;240:106866. doi: 10.1016/j.actatropica.2023.106866. Epub 2023 Feb 18.

DOI:10.1016/j.actatropica.2023.106866

PMID:36801451

Abstract

BACKGROUND

Entamoeba infection-associated diseases (EIADs) in humans are a worldwide public health problem, but there is a lack of a global picture of EIADs, which is vital to prevention and control.

METHODS

We applied 2019 Global Burden of Disease (GBD) data collected from multiple sources at global, national and regional levels. The disability-adjusted life years (DALYs) with corresponding 95% uncertainty intervals (95% UIs) were extracted as the main measure of the burden of EIADs. The Joinpoint regression model was used to estimate the trends of age-standardised DALY rates by age, sex, geographical region, and sociodemographic index (SDI). Besides, a generalized linear model was conducted to analyze the influence of sociodemographic factors on the DALY rate of EIADs.

RESULTS

In 2019, there were 2,539,799 (95% UI 850,865-6,186,972) DALY cases attributable to Entamoeba infection, and the global age-standardised DALY rate of EIADs was 36.77/100,000 (95% UI: 12.03-90.49). Although over the past 30 years, the age-standardised DALY rate of EIADs presented significantly declining trends [average annual percent change (AAPC) = -3.79%, 95% CI: -4.05% - -3.53%], it has remained a heavy burden among the age group of <5 years (257.43/100,000, 95% UI: 67.73-676.78) and the low SDI regions (100.47/100,000, 95% UI: 32.27-249.09). The age-standardized DALY rate in high-income North America and Australia had an increasing trend (AAPC = 0.38%, 95% CI: 0.47% - 0.28% and 0.38%, 95% CI: 0.46% - 0.29%, respectively). Furthermore, the DALY rates in high SDI regions showed statistically significant increasing trends among the age groups of 14-49, 50-69 years and 70+ years, with AAPCs of 1.01% (95% CI: 0.87% - 1.15%), 1.58% (95% CI: 1.43% - 1.73%), and 2.93% (95% CI: 2.58% - 3.29%), respectively.

CONCLUSIONS

Over the past 30 years, the burden of EIADs has declined significantly. However, it has still caused a high burden in the low SDI regions and the age group of <5 years. At the same time, in adults and the elderly of the high SDI regions, the increasing trends of Entamoeba infection-associated burden should also be given more attention.

摘要

背景

人类的溶组织内阿米巴感染相关疾病（EIADs）是一个全球性的公共卫生问题，但目前缺乏EIADs的全球概况，而这对预防和控制至关重要。

方法

我们应用了从全球、国家和区域层面的多个来源收集的2019年全球疾病负担（GBD）数据。提取了具有相应95%不确定性区间（95%UIs）的伤残调整生命年（DALYs）作为EIADs负担的主要衡量指标。采用Joinpoint回归模型来估计按年龄、性别、地理区域和社会人口指数（SDI）划分的年龄标准化DALY率趋势。此外，进行了广义线性模型分析社会人口因素对EIADs的DALY率的影响。

结果

2019年，有2,539,799例（95%UI 850,865 - 6,186,972）DALY病例归因于溶组织内阿米巴感染，EIADs的全球年龄标准化DALY率为36.77/10万（95%UI：12.03 - 90.49）。尽管在过去30年中，EIADs的年龄标准化DALY率呈现出显著下降趋势[平均年变化百分比（AAPC）=-3.79%，95%CI：-4.05% - -3.53%]，但在<5岁年龄组（257.43/10万，95%UI：67.73 - 676.78）和低SDI地区（100.47/10万，95%UI：32.27 - 249.09）中，其负担仍然很重。高收入的北美和澳大利亚的年龄标准化DALY率呈上升趋势（AAPC分别为0.38%，95%CI：0.47% - 0.28%和0.38%，95%CI：0.46% - 0.29%）。此外，在高SDI地区，14 - 49岁、50 - 69岁和70岁及以上年龄组的DALY率呈现出统计学上显著的上升趋势，AAPC分别为1.01%（95%CI：0.87% - 1.15%）、1.58%（95%CI：1.43% - 1.73%）和2.93%（95%CI：2.58% - 3.29%）。