Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; National Health Commission of China (NHC) Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan 250012, China.
Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China; National Health Commission of China (NHC) Key Laboratory of Health Economics and Policy Research (Shandong University), Jinan 250012, China.
Child Abuse Negl. 2024 Jul;153:106818. doi: 10.1016/j.chiabu.2024.106818. Epub 2024 May 1.
Childhood sexual abuse (CSA) is a severe global problem associated with alcohol use disorder (AUD). Previous studies have confirmed this relationship; however, there is a lack of research on the disease burden of AUD attributable to CSA.
To analyze global spatiotemporal trends and differences in the disease burden of AUD attributable to CSA and its relationship with age, sex, and the sociodemographic index (SDI).
Data from the Global Burden of Disease 2019 Public Database.
Summary exposure value (SEV) was used to evaluate CSA. Disability-adjusted life year (DALY), years lived with disability (YLD), years of life lost (YLL), and their annual rates of change were used to evaluate disease burden. Cluster analysis based on Ward's method was used to examine the global burden associated with age, sex, and SDI. A 95 % uncertainty intervals (UI), excluding 0, was considered statistically significant.
In 2019, 1.63 million (95 % UI 0.23-3.90 million) DALYs of AUD were caused by CSA and the age-standardized rates (ASRs) of DALY was 19.77 (95 % UI 2.78-47.46) globally. Annual rates of change in DALY of people over 65 years of age increased from 1990 to 2019 in all regions except the High-middle SDI regions. The ASRs of DALY of females in High SDI regions, were always at a much higher level than other SDI regions, and showed an upward trend from 1990 to 2019 (DALY 1990: 20.38 [95 % UI 2.87-47.77], 2019: 23.61 [95 % UI 3.55-54.94]).
Substantial geographical differences were observed in the burden of AUD attributable to CSA. The level of CSA exposure was inconsistent with the related burden of AUD in different regions according to the sociodemographic index. The burden of disease increased in the elderly population and in females in high sociodemographic index regions.
儿童期性虐待（CSA）是一个严重的全球性问题，与酒精使用障碍（AUD）有关。先前的研究已经证实了这种关系；然而，关于 CSA 导致的 AUD 的疾病负担的研究还很缺乏。
分析 CSA 导致的 AUD 的疾病负担的全球时空趋势和差异，以及其与年龄、性别和社会人口指数（SDI）的关系。
来自全球疾病负担 2019 年公共数据库的数据。
采用综合暴露值（SEV）评估 CSA。采用残疾调整生命年（DALY）、残疾生存年（YLD）、生命损失年（YLL）及其年变化率来评估疾病负担。基于 Ward 法的聚类分析用于检查与年龄、性别和 SDI 相关的全球负担。95%置信区间（UI），不包括 0，被认为具有统计学意义。
2019 年，CSA 导致 163 万（95% UI 0.23-3.90 万）例 AUD 的 DALY，全球年龄标准化率（ASR）为 19.77（95% UI 2.78-47.46）。除了高-中社会人口指数地区外，所有地区的 65 岁以上人群的 DALY 年变化率从 1990 年到 2019 年都在增加。高社会人口指数地区女性的 DALY ASR 一直高于其他社会人口指数地区，并且从 1990 年到 2019 年呈上升趋势（DALY 1990：20.38[95% UI 2.87-47.77]，2019：23.61[95% UI 3.55-54.94]）。
CSA 导致的 AUD 负担存在显著的地域差异。根据社会人口指数，不同地区 CSA 暴露水平与相关 AUD 负担不一致。疾病负担在老年人口和高社会人口指数地区的女性中增加。
