Doherty Connor J, Chang Jou-Chung, Thompson Benjamin P, Swenson Erik R, Foster Glen E, Dominelli Paolo B
Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Washington, USA.
High Alt Med Biol. 2023 Mar;24(1):7-18. doi: 10.1089/ham.2022.0134. Epub 2023 Feb 20.
Doherty, Connor J., Jou-Chung Chang, Benjamin P. Thompson, Erik R. Swenson, Glen E. Foster, and Paolo B. Dominelli. The impact of acetazolamide and methazolamide on exercise performance in normoxia and hypoxia. . 24:7-18, 2023.-Carbonic anhydrase (CA) inhibitors are commonly prescribed for acute mountain sickness (AMS). In this review, we sought to examine how two CA inhibitors, acetazolamide (AZ) and methazolamide (MZ), affect exercise performance in normoxia and hypoxia. First, we briefly describe the role of CA inhibition in facilitating the increase in ventilation and arterial oxygenation in preventing and treating AMS. Next, we detail how AZ affects exercise performance in normoxia and hypoxia and this is followed by a discussion on MZ. We emphasize that the overarching focus of the review is how the two drugs potentially affect exercise performance, rather than their ability to prevent/treat AMS , their interrelationship will be discussed. Overall, we suggest that AZ hinders exercise performance in normoxia, but may be beneficial in hypoxia. Based upon head-to-head studies of AZ and MZ in humans on diaphragmatic and locomotor strength in normoxia, MZ may be a better CA inhibitor when exercise performance is crucial at high altitude.
多尔蒂，康纳·J.，张佑中，本杰明·P.·汤普森，埃里克·R.·斯文森，格伦·E.·福斯特，以及保罗·B.·多米内利。乙酰唑胺和甲醋唑胺对常氧和低氧状态下运动表现的影响。《……》2023年第24卷：第7 - 18页。——碳酸酐酶（CA）抑制剂常用于治疗急性高原病（AMS）。在本综述中，我们试图研究两种CA抑制剂，乙酰唑胺（AZ）和甲醋唑胺（MZ），如何影响常氧和低氧状态下的运动表现。首先，我们简要描述CA抑制在促进通气增加和动脉氧合以预防和治疗AMS中的作用。接下来，我们详细阐述AZ如何影响常氧和低氧状态下的运动表现，然后讨论MZ。我们强调，本综述的总体重点是这两种药物如何潜在地影响运动表现，而非它们预防/治疗AMS的能力，且将讨论它们之间的相互关系。总体而言，我们认为AZ在常氧状态下会阻碍运动表现，但在低氧状态下可能有益。基于在常氧状态下对AZ和MZ在人体膈肌和运动力量方面的直接比较研究，当运动表现对高原地区至关重要时，MZ可能是一种更好的CA抑制剂。
