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儿童中幽门螺杆菌究竟是不是致病菌?

Is Helicobacter pylori Anyway Pathogen in Children?

机构信息

Azienda USL-IRCCS di Reggio Emilia, Maternal and Child Department, Pediatric Unit, Sant'Anna Hospital, Castelnovo ne Monti, Reggio Emilia, Italy.

Week Hospital, Pietro Barilla Children's Hospital, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

出版信息

Inquiry. 2023 Jan-Dec;60:469580231154650. doi: 10.1177/00469580231154650.

DOI:10.1177/00469580231154650
PMID:36803205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9940224/
Abstract

() infection is a continuous challenge for both gastroenterologists and pediatricians. The international guidelines regarding diagnostic and treatment pathways differ between adults and children. The pediatric guidelines are more restrictive because children are rarely affected by serious consequences, particularly in Western countries. Therefore, infected children should be treated only after a careful case-by-case evaluation by a pediatric gastroenterologist. In any case, recent studies are confirming an increasingly all-around pathological role of even in asymptomatic children. For these reasons, following the current evidence, we feel that -infected children could be treated starting in pre-adolescence, particularly in Eastern countries, because their stomachs have already begun to develop the biomarkers of gastric damage. Therefore, we believe that is anyway pathogen in children. Nevertheless, the possible beneficial role of in humans has not yet been conclusively disproved.

摘要

幽门螺杆菌感染对于消化科医生和儿科医生来说都是一个持续的挑战。国际上针对诊断和治疗路径的指南在成人和儿童之间存在差异。儿科指南更为严格,因为儿童很少受到严重后果的影响,特别是在西方国家。因此,感染的儿童应由儿科胃肠病学家进行仔细的个体评估后,才考虑进行治疗。无论如何,最近的研究证实了 即使在无症状儿童中也具有越来越全面的病理作用。基于这些原因,根据现有证据,我们认为在东亚国家,感染的儿童可以在青春期前开始治疗,因为他们的胃已经开始出现胃损伤的生物标志物。因此,我们认为 无论如何都是儿童的病原体。然而, 在人类中可能具有的有益作用尚未被最终否定。