Kulkarni Radha, Fanse Suraj, Burgess Diane J
School of Pharmacy, University of Connecticut, Storrs, CT, USA.
Expert Opin Drug Deliv. 2023 Mar;20(3):413-434. doi: 10.1080/17425247.2023.2181332. Epub 2023 Feb 22.
Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, several dosage forms have been developed for localized as well as systemic drug delivery at different anatomical sites.
The objective of this review is to provide a detailed understanding of the different aspects of MDDS. Part II describes the origin and evolution of MDDS, followed by a discussion of the properties of mucoadhesive polymers. Finally, a synopsis of the different commercial aspects of MDDS, recent advances in the development of MDDS for biologics and COVID-19 as well as future perspectives are provided.
A review of the past reports and recent advances reveal MDDS as highly versatile, biocompatible, and noninvasive drug delivery systems. The rise in the number of approved biologics, the introduction of newer highly efficient thiomers, as well as the recent advances in the field of nanotechnology have led to several excellent applications of MDDS, which are predicted to grow significantly in the future.
粘膜粘附性给药系统（MDDS）是专门设计用于与上皮细胞的粘膜层相互作用并结合，以实现局部、延长和/或靶向给药。在过去的40年里，已经开发了几种剂型用于在不同解剖部位进行局部和全身给药。
本综述的目的是详细介绍MDDS的不同方面。第二部分描述了MDDS的起源和发展，随后讨论了粘膜粘附性聚合物的特性。最后，概述了MDDS的不同商业方面、用于生物制品和COVID-19的MDDS开发的最新进展以及未来展望。
对过去报告和最新进展的回顾表明，MDDS是高度通用、生物相容且无创的给药系统。获批生物制品数量的增加、新型高效硫醇聚合物的引入以及纳米技术领域的最新进展，已带来了MDDS的一些出色应用，预计其在未来将显著增长。
