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天然产物及其衍生物防治阿尔茨海默病的研究进展。

Research progress of natural products and their derivatives against Alzheimer's disease.

机构信息

Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, China.

Center of Medical Functional Experiment, Yanbian University College of Medicine, Yanji, China.

出版信息

J Enzyme Inhib Med Chem. 2023 Dec;38(1):2171026. doi: 10.1080/14756366.2023.2171026.

DOI:10.1080/14756366.2023.2171026
PMID:36803484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9946335/
Abstract

Alzheimer's disease (AD), a persistent neurological dysfunction, has an increasing prevalence with the aging of the world and seriously threatens the health of the elderly. Although there is currently no effective treatment for AD, researchers have not given up, and are committed to exploring the pathogenesis of AD and possible therapeutic drugs. Natural products have attracted considerable attention owing to their unique advantages. One molecule can interact with multiple AD-related targets, thus having the potential to be developed in a multi-target drug. In addition, they are amenable to structural modifications to increase interaction and decrease toxicity. Therefore, natural products and their derivatives that ameliorate pathological changes in AD should be intensively and extensively studied. This review mainly presents research on natural products and their derivatives for the treatment of AD.

摘要

阿尔茨海默病（AD）是一种持续的神经功能障碍，随着世界人口老龄化的加剧，其发病率不断上升，严重威胁着老年人的健康。目前虽然尚无有效的 AD 治疗方法，但研究人员并未放弃，致力于探索 AD 的发病机制及可能的治疗药物。天然产物由于其独特的优势而受到广泛关注。一个分子可以与多个 AD 相关靶点相互作用，因此具有开发多靶点药物的潜力。此外，它们易于进行结构修饰以增加相互作用和降低毒性。因此，应该深入广泛地研究能够改善 AD 病理变化的天然产物及其衍生物。本文主要介绍了用于治疗 AD 的天然产物及其衍生物的研究进展。

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2
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Oxid Med Cell Longev. 2022 Jun 24;2022:9154295. doi: 10.1155/2022/9154295. eCollection 2022.
3
DSNN: A DenseNet-Based SNN for Explainable Brain Disease Classification.DSNN：一种基于密集连接网络的用于可解释脑疾病分类的脉冲神经网络
受香豆素启发的双功能杂化物作为一类具有强效疗效的新型抗阿尔茨海默病药物的研发。
RSC Med Chem. 2024 Dec 11. doi: 10.1039/d4md00782d.
4
Therapeutic Options in Alzheimer's Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic Activity.阿尔茨海默病的治疗选择：从经典的乙酰胆碱酯酶抑制剂到具有多效活性的多靶点药物。
Life (Basel). 2024 Nov 26;14(12):1555. doi: 10.3390/life14121555.
5
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6
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7
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Front Pharmacol. 2024 Jul 24;15:1423060. doi: 10.3389/fphar.2024.1423060. eCollection 2024.
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Neural Regen Res. 2025 Sep 1;20(9):2706-2726. doi: 10.4103/NRR.NRR-D-23-01681. Epub 2024 Jul 29.
9
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Front Aging Neurosci. 2024 May 22;16:1414956. doi: 10.3389/fnagi.2024.1414956. eCollection 2024.
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4
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8
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9
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