Terukina Takayuki, Tanaka Jun, Takayama Yumi, Osanai Kaede, Kino Shusuke, Kanazawa Takanori, Kondo Hiromu
Department of Pharmaceutical Engineering and Drug Delivery Sciences, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Drug Dev Ind Pharm. 2023 Jan;49(1):75-83. doi: 10.1080/03639045.2023.2182127. Epub 2023 Mar 1.
To evaluate the possible application of Sangelose as an alternative to gelatin and carrageenan for the development of film substrates, and to examine the effect of glycerol and α-cyclodextrin (α-CyD) on the viscoelastic properties of Sangelose-based gels and the physical properties of the films.
Sangelose-based gels/films can serve as a potential viable alternative to gelatin and carrageenan in pharmaceutical applications.
Glycerol (a plasticizer) and α-CyD (a functional additive) were added to Sangelose, and gels and films were prepared. The gels were evaluated by dynamic viscoelasticity measurements, and the films were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy, tensile tests, and contact angle measurements. Soft capsules were prepared using the formulated gels.
The strength of the gels was affected when only glycerol was added to Sangelose and α-CyD addition resulted in rigid gels. However, the addition of α-CyD with 10% glycerol weakened the gels. Tensile tests suggested that glycerol addition affected the formability and malleability of the films, while α-CyD addition affected their formability and elongation properties. The addition of 10% glycerol and α-CyD did not affect the flexibility of the films, suggesting that the malleability and strength were impacted. Soft capsules could not be prepared by adding only glycerol or α-CyD to Sangelose. Soft capsules with favorable disintegration behavior were obtained upon adding α-CyD to gels along with 10% glycerol.
Sangelose combined with a suitable amount of glycerol and α-CyD has preferable characteristics for film formation and may have potential applications in the pharmaceutical and health food sectors.
评估桑根低聚糖作为明胶和卡拉胶替代品用于制备薄膜基质的可能性，并研究甘油和α-环糊精（α-CyD）对基于桑根低聚糖的凝胶的粘弹性以及薄膜物理性能的影响。
基于桑根低聚糖的凝胶/薄膜在药物应用中可作为明胶和卡拉胶潜在的可行替代品。
将甘油（一种增塑剂）和α-CyD（一种功能添加剂）添加到桑根低聚糖中，制备凝胶和薄膜。通过动态粘弹性测量评估凝胶，通过扫描电子显微镜、傅里叶变换红外光谱、拉伸试验和接触角测量评估薄膜。使用配制好的凝胶制备软胶囊。
仅向桑根低聚糖中添加甘油时，凝胶强度受到影响，而添加α-CyD会导致凝胶变硬。然而，添加10%甘油的α-CyD会使凝胶变弱。拉伸试验表明，添加甘油会影响薄膜的可成型性和延展性，而添加α-CyD会影响其可成型性和伸长性能。添加10%甘油和α-CyD不会影响薄膜的柔韧性，表明延展性和强度受到了影响。仅向桑根低聚糖中添加甘油或α-CyD无法制备软胶囊。在向凝胶中添加α-CyD以及10%甘油后，获得了具有良好崩解行为的软胶囊。
桑根低聚糖与适量的甘油和α-CyD结合具有较好的成膜特性，可能在制药和保健食品领域具有潜在应用。
