黄素光催化促进甲苯和 -苯二胺的有氧交叉脱氢偶联反应，用于方便地合成苯并咪唑。
Aerobic cross-dehydrogenative coupling of toluenes and -phenylenediamines by flavin photocatalysis for the facile synthesis of benzimidazoles.
机构信息
Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504 Japan.
出版信息
Org Biomol Chem. 2023 Mar 8;21(10):2081-2085. doi: 10.1039/d3ob00113j.
PMID:36804653
Abstract
Herein, we demonstrate a green atom-economical synthesis of benzimidazoles the flavin-photocatalysed aerobic oxidative cross-dehydrogenative coupling of toluenes and -phenylenediamines. The proposed metal-free reaction proceeds in methanol/HO under visible light irradiation by consuming only molecular oxygen from atmospheric air and produces only water as waste.
摘要
在此，我们展示了苯并咪唑的绿色原子经济性合成方法，即通过黄素光催化有氧氧化交叉脱氢偶联甲苯和 -苯二胺。所提出的无金属反应在甲醇/HO 中进行，在可见光照射下，仅消耗大气中的氧气作为唯一的氧化剂，并仅产生水作为废物。
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