Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504 Japan.
Org Lett. 2020 Dec 4;22(23):9244-9248. doi: 10.1021/acs.orglett.0c03458. Epub 2020 Nov 23.
Inspired by the photochemical mechanism of a plant blue-light receptor, a unique flavin-based photocatalytic system was developed for the chemoselective heterocoupling of two different thiols, which enabled the facile synthesis of unsymmetrical disulfides. Owing to the redox- and photo-organocatalysis of flavin, the coupling reaction took place under mild metal-free conditions and visible light irradiation with the use of air, which is recognized as the ideal green oxidant.
受植物蓝光受体的光化学机制启发，开发了一种独特的基于黄素的光催化体系，用于两种不同硫醇的化学选择性杂偶联，从而实现了不对称二硫化物的简便合成。由于黄素的氧化还原和光有机催化作用，偶联反应在温和的无金属条件下，在可见光照射下，使用空气进行，空气被认为是理想的绿色氧化剂。
