S N Medical College, Jodhpur, India.
S N Medical College, Jodhpur, India.
Diabetes Metab Syndr. 2023 Feb;17(2):102725. doi: 10.1016/j.dsx.2023.102725. Epub 2023 Feb 11.
Peripheral neuropathy is the most common microvascular complication of diabetes mellitus. In subjects with type 1 diabetes (T1D) relationship of C-peptide levels and neuropathy has been observed in several studies, however, there are very few studies in type 2 diabetes (T2D) subjects. In this study we aim to assess the association of C-peptide levels with peripheral neuropathy in Indian subjects with T2D.
One hundred patients of T2D were included in this study. Clinical and laboratory parameter was assessed for all participants. The C-peptide level was measured by fluorometric enzyme immunoassay method. Assessment of diabetic peripheral neuropathy was based on diabetic neuropathy symptom score and the diabetic neuropathy examination scores.
Total 100 patients completed the study. Mean age of subjects was 60.03 years and male: female ratio was 1.17. Peripheral neuropathy was detected in 47% of subjects evaluated. Subjects were further divided in to neuropathy group and no-neuropathy group for analysis. Age in neuropathy group was significantly higher than no-neuropathy group [65.62 ± 10.5 vs 55.08 ± 9.41 yrs (p-value <0.0001)] and similarly duration of T2D was significantly higher in neuropathy group [10.11 ± 6.13 vs 4.16 ± 3.7 yrs (p-value <0.0001)]. Importantly mean fasting C-peptide (2.27 ± 0.98 vs 3.12 ± 0.84 ng/ml) and mean post meal C-peptide (4.27 ± 1.34 vs 5.33 ± 0.89 ng/ml) were significantly lower in neuropathy group compared to no-neuropathy group. An association of HbA1c level and neuropathy was statistically not significant (p = 0.793).
Serum C-peptide concentrations are associated with peripheral neuropathy in T2DM patients, independent of the degree of glycemic control.
周围神经病变是糖尿病最常见的微血管并发症。在 1 型糖尿病（T1D）患者中，已有多项研究观察到 C 肽水平与神经病变之间的关系，但在 2 型糖尿病（T2D）患者中，此类研究很少。本研究旨在评估 C 肽水平与印度 T2D 患者周围神经病变的关系。
本研究纳入了 100 例 T2D 患者。对所有参与者进行了临床和实验室参数评估。C 肽水平采用荧光酶免疫分析法测定。糖尿病周围神经病变的评估基于糖尿病周围神经病变症状评分和糖尿病周围神经病变检查评分。
共有 100 例患者完成了本研究。受试者的平均年龄为 60.03 岁，男女比例为 1.17。评估的受试者中，47%患有周围神经病变。受试者进一步分为神经病变组和无神经病变组进行分析。神经病变组的年龄明显高于无神经病变组[65.62±10.5 岁比 55.08±9.41 岁（p 值<0.0001)]，同样，T2D 的病程在神经病变组也明显更长[10.11±6.13 岁比 4.16±3.7 岁（p 值<0.0001)]。重要的是，神经病变组的空腹 C 肽均值（2.27±0.98 ng/ml 比 3.12±0.84 ng/ml）和餐后 C 肽均值（4.27±1.34 ng/ml 比 5.33±0.89 ng/ml）均明显低于无神经病变组。HbA1c 水平与神经病变的相关性无统计学意义（p=0.793）。
血清 C 肽浓度与 T2DM 患者的周围神经病变相关，与血糖控制程度无关。
