Department of Neurology, Movement Disorders and Neuromodulation Unit, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health, Berlin, Germany.
Mov Disord. 2023 May;38(5):894-899. doi: 10.1002/mds.29347. Epub 2023 Feb 20.
Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side-effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13-30 Hz). We hypothesize that this pattern is symptom-specific, thus accompanying DBS-induced slowness in dystonia.
In 6 dystonia patients, pallidal rest recordings with a sensing-enabled DBS device were performed and tapping speed was assessed using marker-less pose estimation over 5 time points following cessation of DBS.
After cessation of pallidal stimulation, movement speed increased over time (P < 0.01). A linear mixed-effects model revealed that pallidal beta activity explained 77% of the variance in movement speed across patients (P = 0.01).
The association between beta oscillations and slowness across disease entities provides further evidence for symptom-specific oscillatory patterns in the motor circuit. Our findings might help DBS therapy improvements, as DBS-devices able to adapt to beta oscillations are already commercially available. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
苍白球深部脑刺激（DBS）可有效缓解肌张力障碍患者的症状，但可能会引起运动迟缓等副作用。在帕金森病中，运动缓慢与β 振荡（13-30 Hz）增加有关。我们假设这种模式具有症状特异性，因此伴随 DBS 诱导的肌张力障碍患者运动迟缓。
在 6 名肌张力障碍患者中，使用具有感应功能的 DBS 设备进行苍白球静息记录，并在停止 DBS 后的 5 个时间点使用无标记姿势估计评估叩击速度。
停止苍白球刺激后，运动速度随时间增加（P < 0.01）。线性混合效应模型显示，苍白球β 活动解释了患者间运动速度变化的 77%（P = 0.01）。
不同疾病实体中β 振荡与运动迟缓之间的关联为运动回路中具有症状特异性的振荡模式提供了进一步证据。我们的研究结果可能有助于 DBS 治疗的改进，因为能够适应β 振荡的 DBS 设备已经商业化。© 2023 作者。运动障碍由 Wiley Periodicals LLC 代表国际帕金森病和运动障碍协会出版。
