Department of Biochemistry and Molecular Biology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa, USA.
Biol Cell. 2023 May;115(5):e202200108. doi: 10.1111/boc.202200108. Epub 2023 Mar 8.
Much attention has been dedicated to understanding how cells sense and respond to mechanical forces. The types of forces cells experience as well as the repertoire of cell surface receptors that sense these forces have been identified. Key mechanisms for transmitting that force to the cell interior have also emerged. Yet, how cells process mechanical information and integrate it with other cellular events remains largely unexplored. Here we review the mechanisms underlying mechanotransduction at cell-cell and cell-matrix adhesions, and we summarize the current understanding of how cells integrate information from the distinct adhesion complexes with cell metabolism.
人们已经投入了大量的关注来理解细胞如何感知和响应机械力。细胞所经历的力的类型以及感知这些力的细胞表面受体的种类已经被确定。将力传递到细胞内部的关键机制也已经出现。然而，细胞如何处理机械信息并将其与其他细胞事件整合在一起，在很大程度上仍然没有得到探索。在这里，我们回顾了细胞-细胞和细胞-基质黏附处机械转导的基础机制，并总结了目前对细胞如何将来自不同黏附复合物的信息与细胞代谢整合的理解。
