Schuette W H, Mudd C P
Division of Research Services, National Institutes of Health, Bethesda, MD 20892.
J Biochem Biophys Methods. 1987 Jun;14(3):167-75. doi: 10.1016/0165-022x(87)90019-4.
An iterative method for the deconvolution of microcalorimetry thermograms suitable for small digital computers is presented. The method employs a measured impulse response function directly as the deconvolution kernel, thus explicit system simulation is not required. Data are presented showing the performance of the method and the exchange of signal-to-noise ratio for time resolution that is made when deconvolution techniques are employed. An improvement in the system time resolution of fifty times is demonstrated with measured data.