Runyon B A
Department of Medicine, University of New Mexico, School of Medicine, Albuquerque.
J Clin Gastroenterol. 1987 Oct;9(5):541-2. doi: 10.1097/00004836-198710000-00010.
Symptomatic relapses of autoimmune chronic active hepatitis during steroid withdrawal are well known. However, the exquisite sensitivity of some patients to very small decrements in steroid dose has not been emphasized. Reported here are two patients who developed, during steroid withdrawal, eight relapses of their disease; symptomatic and biochemical relapses occurred within 3 weeks after prednisone had been reduced from 2.5 mg every other day to 1.75 mg every other day in one patient and from 2.5 mg per day to zero in the other. "Physiologic" doses of prednisone may be therapeutic in some patients with autoimmune chronic active hepatitis.
自身免疫性慢性活动性肝炎在停用类固醇期间出现症状性复发是众所周知的。然而，一些患者对类固醇剂量非常小的减少极为敏感这一点尚未得到强调。本文报告了两名患者，他们在停用类固醇期间疾病复发了八次；一名患者在泼尼松从隔日2.5毫克减至隔日1.75毫克后的3周内出现了症状性和生化指标复发，另一名患者在泼尼松从每日2.5毫克减至零后的3周内出现了同样情况。“生理”剂量的泼尼松对一些自身免疫性慢性活动性肝炎患者可能具有治疗作用。
