Mistilis S P, Vickers C R, Darroch M H, McCarthy S W
Med J Aust. 1985 Nov 11;143(10):463-5. doi: 10.5694/j.1326-5377.1985.tb123140.x.
A 51-year-old man whose aggressive autoimmune chronic active hepatitis had been treated with prednisone for five years, was treated with cyclosporin for 12 months. The disease had become unresponsive to high doses of prednisone and the side-effects had become disabling. Azathioprine could not be used because of drug hypersensitivity. With cyclosporin therapy the patient's symptoms disappeared for the first time since the onset of his illness, his liver enzyme levels fell almost to normal values and virtually no side-effects occurred. We suggest that cyclosporin be used on a clinical trial basis in patients with autoimmune chronic active hepatitis that is resistant to prednisone and azathioprine therapy.
一名51岁男性，其侵袭性自身免疫性慢性活动性肝炎已用泼尼松治疗5年，后用环孢素治疗12个月。该疾病对高剂量泼尼松已无反应，且副作用已使其丧失活动能力。由于药物过敏，不能使用硫唑嘌呤。采用环孢素治疗后，患者症状自发病以来首次消失，肝酶水平几乎降至正常，且几乎未出现副作用。我们建议，对于对泼尼松和硫唑嘌呤治疗耐药的自身免疫性慢性活动性肝炎患者，可在临床试验基础上使用环孢素。
