Person J L, McHutchison J G, Fong T L, Redeker A G
Division of Gastrointestinal and Liver Diseases, University of Southern California, School of Medicine, Los Angeles.
J Clin Gastroenterol. 1993 Dec;17(4):317-20. doi: 10.1097/00004836-199312000-00012.
Few alternative treatments are available for those patients with autoimmune chronic active hepatitis who fail to respond to the conventional treatment of corticosteroids. Such patients have a poor prognosis and frequently require liver transplantation. We report a patient with autoimmune hepatitis who failed treatment with corticosteroids and azathioprine. He responded to treatment with cyclosporine but relapsed with its discontinuation; reinstitution of the cyclosporine again induced remission. Cyclosporine appears to be an effective alternative treatment in patients with steroid-resistant, autoimmune chronic active hepatitis; its use may preclude or delay liver transplantation.
对于那些对传统皮质类固醇治疗无反应的自身免疫性慢性活动性肝炎患者，几乎没有其他替代治疗方法。这类患者预后较差，经常需要进行肝移植。我们报告了一名自身免疫性肝炎患者，他对皮质类固醇和硫唑嘌呤治疗无效。他对环孢素治疗有反应，但停药后复发；再次使用环孢素又诱导缓解。环孢素似乎是对类固醇耐药的自身免疫性慢性活动性肝炎患者的一种有效替代治疗方法；其使用可能避免或延迟肝移植。
