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Incidence of Brain Metastases and Preliminary Evidence of Intracranial Activity With Sotorasib in Patients With -Mutant Non-Small-Cell Lung Cancer.

作者信息

Lamberti Giuseppe, Aizer Ayal, Ricciuti Biagio, Alessi Joao V, Pecci Federica, Tseng Shu-Chi, Sholl Lynette M, Nishino Mizuki, Awad Mark M

机构信息

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA.

出版信息

JCO Precis Oncol. 2023 Feb;7:e2200621. doi: 10.1200/PO.22.00621.

DOI:10.1200/PO.22.00621
PMID:36809054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10309542/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/8ef84ec29dfa/po-7-e2200621-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/e09513137e45/po-7-e2200621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/bff2147ce2a4/po-7-e2200621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/d10969f771c4/po-7-e2200621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/e86dc711d790/po-7-e2200621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/df6edeceb32d/po-7-e2200621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/ab1a0fb39d74/po-7-e2200621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/8ef84ec29dfa/po-7-e2200621-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/e09513137e45/po-7-e2200621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/bff2147ce2a4/po-7-e2200621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/d10969f771c4/po-7-e2200621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/e86dc711d790/po-7-e2200621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/df6edeceb32d/po-7-e2200621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/ab1a0fb39d74/po-7-e2200621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebde/10309542/8ef84ec29dfa/po-7-e2200621-g008.jpg

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N Engl J Med. 2022 Jul 14;387(2):120-131. doi: 10.1056/NEJMoa2204619. Epub 2022 Jun 3.
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Post Hoc Analysis of Lorlatinib Intracranial Efficacy and Safety in Patients With -Positive Advanced Non-Small-Cell Lung Cancer From the Phase III CROWN Study.
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