Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Canon Inc., Tokyo, Japan.
PLoS One. 2023 Feb 21;18(2):e0282057. doi: 10.1371/journal.pone.0282057. eCollection 2023.
To explore the effect of photodynamic therapy (PDT) on the choroid of medial area from optic disc and factors correlated with treatment outcomes, we evaluated choroidal changes using ultra-widefield optical coherence tomography (UWF-OCT) after PDT for central serous chorioretinopathy (CSC).
In this retrospective case-series, we included CSC patients who received a standard-dose of full-fluence PDT. UWF-OCT were examined at baseline and 3 months after treatment. We measured choroidal thickness (CT), classified into central, middle, and peripheral sectors. We examined CT changes after PDT by sectors and treatment outcome.
Twenty-two eyes of 21 patients (20 males; mean age 58.7 ± 12.3 years) were included. CT reduction after PDT was significant in all sectors, including peripheral areas: supratemporal, 330.5 ± 90.6 μm vs. 237.0 ± 53.2 μm; infratemporal, 240.0 ± 89.4 μm vs. 209.9 ± 55.1 μm; supranasal, 237.7 ± 59.8 vs 209.3 ± 69.3 μm; infranasal, 172.6 ± 47.2 μm vs. 155.1 ± 38.2 μm (P < 0.001, for all). In patients with retinal fluid resolution, despite no apparent difference in baseline CT, there was more significant reduction after PDT in supratemporal and supranasal peripheral sectors, compared with patients without resolution: supratemporal, 41.9 ± 30.3 μm vs. -1.6 ± 22.7 μm; supranasal, 24.7 ± 15.3 μm vs. 8.5 ± 3.6 μm (P < 0.019, for both).
Whole CT decreased after PDT, including in medial areas from optic disc. This may be associated with the treatment response of PDT for CSC.
通过超广角光学相干断层扫描（UWF-OCT）评估光动力疗法（PDT）治疗中心性浆液性脉络膜视网膜病变（CSC）后脉络膜的变化，探讨 PDT 对视盘内侧区域脉络膜的影响及其与治疗效果相关的因素。
本回顾性病例系列研究纳入了接受标准剂量全光强 PDT 的 CSC 患者。治疗前和治疗后 3 个月进行 UWF-OCT 检查。我们测量脉络膜厚度（CT），并将其分为中央、中间和周边区。我们通过各区和治疗效果评估 PDT 后 CT 的变化。
21 例患者（20 名男性；平均年龄 58.7 ± 12.3 岁）的 22 只眼纳入研究。所有区包括周边区（颞上、颞下、鼻上和鼻下）的 CT 在 PDT 后均显著降低：颞上，330.5 ± 90.6 μm 比 237.0 ± 53.2 μm；颞下，240.0 ± 89.4 μm 比 209.9 ± 55.1 μm；鼻上，237.7 ± 59.8 μm 比 209.3 ± 69.3 μm；鼻下，172.6 ± 47.2 μm 比 155.1 ± 38.2 μm（均 P < 0.001）。在视网膜液休吸收的患者中，尽管基线 CT 无明显差异，但与未吸收的患者相比，颞上和鼻上周边区的 CT 在 PDT 后下降更为明显：颞上，41.9 ± 30.3 μm 比 -1.6 ± 22.7 μm；鼻上，24.7 ± 15.3 μm 比 8.5 ± 3.6 μm（均 P < 0.019）。
PDT 后全 CT 下降，包括视盘内侧区域。这可能与 PDT 治疗 CSC 的疗效有关。
