Funatsu Ryoh, Sonoda Shozo, Terasaki Hiroto, Shiihara Hideki, Mihara Naohisa, Horie Juun, Sakamoto Taiji
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Canon Inc., Tokyo, Japan.
Graefes Arch Clin Exp Ophthalmol. 2023 Apr;261(4):971-979. doi: 10.1007/s00417-022-05905-1. Epub 2022 Nov 19.
To analyze the choroidal morphological changes in central serous chorioretinopathy (CSC) using ultra-widefield (UWF)-optical coherence tomography (OCT).
This single-center, case-control study included 65 CSC eyes (52 males; age, 55.6 ± 13.0 years) and 65 healthy eyes (50 males; age, 57.1 ± 17.9 years). UWF-OCT (viewing angle, 200°) with real-shape correction was used to create an automated choroidal thickness (CT) map. The CT map had three sub-areas: the central (0-30°), middle (30-60°), and peripheral areas (60-100°), and was divided by vertical and horizontal lines. Differences in the CT and the CT change rate (CTCR) from the central to peripheral areas were examined between the CSC and control groups after adjusting for subjects' demographic and clinical factors. Furthermore, we assessed the vortex veins dilation patterns (VVDP) in the macula and examined the CT and the CTCR differences between CSC patients and controls for each VVDP.
CSC patients had greater CT than those of the controls in all sectors (CSC vs. controls, the peripheral area: supratemporal 284.4 ± 71.2 μm vs. 220.4 ± 71.2 μm, infratemporal 263.3 ± 69.2 μm vs. 195.3 ± 52.3 μm, supranasal 251.9 ± 70.3 μm vs. 189.5 ± 58.1 μm, infranasal 193.6 ± 71.2 μm vs. 146.3 ± 48.9 μm, P < 0.0001 for all sectors). The CTCR was apparently larger in CSC eyes than controls only for the upper-dominant type of VVDP (CSC patients vs. controls, supratemporal 32.1 ± 9.9% vs. 4.6 ± 23.1%, infratemporal 44.0 ± 11.2% vs. 25.6 ± 16.8%, supranasal 42.6 ± 9.8% vs. 22.2 ± 19.4%, infranasal 57.6 ± 41.2% vs. 41.2 ± 13.9%, P < 0.0001 for all sectors).
CSC has a thicker choroid, even in the peripheral areas, and the macular choroidal thickening was more severe in the upper-dominant type of VVDP. VVDP may affect the location of excessive fluid.
使用超广角（UWF）光学相干断层扫描（OCT）分析中心性浆液性脉络膜视网膜病变（CSC）的脉络膜形态变化。
这项单中心病例对照研究纳入了65只CSC患眼（52例男性；年龄55.6±13.0岁）和65只健康对照眼（50例男性；年龄57.1±17.9岁）。使用具有真实形状校正功能的UWF-OCT（视角200°）创建自动脉络膜厚度（CT）图。CT图有三个子区域：中央（0-30°）、中间（30-60°）和周边区域（60-100°），并由垂直线和水平线划分。在调整受试者的人口统计学和临床因素后，比较CSC组和对照组从中央到周边区域的CT及CT变化率（CTCR）差异。此外，我们评估了黄斑区涡静脉扩张模式（VVDP），并检查了每种VVDP的CSC患者与对照组之间的CT及CTCR差异。
CSC患者在所有扇形区域的CT均大于对照组（CSC与对照组相比，周边区域：颞上284.4±71.2μm对220.4±71.2μm，颞下263.3±69.2μm对195.3±52.3μm，鼻上251.9±70.3μm对189.5±58.1μm，鼻下193.6±71.2μm对146.3±48.9μm，所有扇形区域P<0.0001）。仅在上部优势型VVDP中，CSC患眼的CTCR明显大于对照组（CSC患者与对照组相比，颞上32.1±9.9%对4.6±23.1%，颞下44.0±11.2%对25.6±16.8%，鼻上42.6±9.8%对22.2±19.4%，鼻下57.6±41.2%对41.2±13.9%，所有扇形区域P<0.0001）。
CSC即使在周边区域也有较厚的脉络膜，并且在上部优势型VVDP中黄斑脉络膜增厚更严重。VVDP可能影响过多液体的位置。
