Innovation Team of Optical Functional Molecular Devices, Inner Mongolia Key Laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China.
Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China.
Org Biomol Chem. 2023 Mar 8;21(10):2096-2100. doi: 10.1039/d3ob00091e.
A Rh(III)-catalyzed C-H bond direct alkylation between 2-arylphthalazine-1,4-diones and α-Cl ketones, which are sp-carbon synthons, under mild conditions has been disclosed. The corresponding phthalazine derivatives are readily obtained in moderate to excellent yields with a wide range of substrates and high functional group tolerance. The practicality and utility of this method are demonstrated by the derivatization of the product.
一种 Rh(III)催化的 2-芳基酞嗪-1,4-二酮与α-Cl 酮（sp 碳合成子）之间的 C-H 键直接烷基化反应在温和条件下被揭示。该反应以中等到优异的产率得到了相应的酞嗪衍生物，具有广泛的底物范围和高官能团容忍度。通过产物的衍生化证明了该方法的实用性和效用。
