Simon B, Knauf H
Klin Wochenschr. 1976 Feb 1;54(3):97-104. doi: 10.1007/BF01468786.
Active buffer transport, e.g. H+ -secretion by stomach and kidney and HCO3--secretion by pancreas and salivary glands, is linked with the presence of a HCO3-stimulated ATP-Phosphohydrolase. In contrast to (Na+ -k+)-ATPase which is considered to be equivalent to the Na+ pump, the HCO3--ATPase requires only one ion for activation and is insensitive to ouabain. The HCO3--ATPase is found in the plasma membrane of the epithelia, but in contrast to the (Na+ -k+)-ATPase it is located in the luminal cell border. The activity of the HCO3--ATPase changes in parallel along with the rate of active buffer transport, a finding which underlines its importance as a transport enzyme. Several disorders of buffer transport are described which are possibly associated with a defect of the HCO3--ATPase system.
主动缓冲转运，例如胃和肾脏分泌氢离子以及胰腺和唾液腺分泌碳酸氢根离子，与碳酸氢根刺激的ATP磷酸水解酶的存在有关。与被认为等同于钠泵的（钠 - 钾）-ATP酶不同，碳酸氢根 - ATP酶仅需一种离子激活，且对哇巴因不敏感。碳酸氢根 - ATP酶存在于上皮细胞的质膜中，但与（钠 - 钾）-ATP酶不同，它位于细胞腔面边界。碳酸氢根 - ATP酶的活性随主动缓冲转运速率平行变化，这一发现突出了其作为转运酶的重要性。文中描述了几种可能与碳酸氢根 - ATP酶系统缺陷相关的缓冲转运紊乱情况。
