School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Pain Centre Versus Arthritis, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK.
Nanomedicine. 2023 Apr;49:102664. doi: 10.1016/j.nano.2023.102664. Epub 2023 Feb 20.
We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached C in the brain at 210 ng/g within 120 min (T), whereas the CBD PCNPs had a C of 94 ng/g at 30 min (T), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.
我们研究了大麻二酚 (CBD) 在中枢神经系统 (CNS) 中的分布情况如何受到两种不同配方的影响，即油包水 (O/W) 纳米乳和聚合物包被纳米颗粒 (PCNPs)。我们观察到，两种给予的 CBD 配方都优先保留在脊髓中，在给予后 10 分钟内，高浓度到达大脑。CBD 纳米乳在 120 分钟时达到脑内 C 为 210ng/g（T），而 CBD PCNPs 在 30 分钟时达到脑内 C 为 94ng/g（T），这表明通过使用 PCNPs 可以实现快速向大脑输送。此外，与 PCNPs 相比，纳米乳给药使 CBD 在大脑中的 AUC 增加了 3.7 倍，表明该部位 CBD 的保留率更高。与各自的空白配方相比，两种配方都表现出即刻的抗伤害感受作用。
