一日禁食对肥胖成年人的皮质醇和脱氢表雄酮每日节律在性别、生物钟类型和年龄方面的影响。
Effect of the one-day fasting on cortisol and DHEA daily rhythm regarding sex, chronotype, and age among obese adults.
作者信息
Marciniak Martyna, Sato Maki, Rutkowski Rafał, Zawada Agnieszka, Juchacz Aldona, Mahadea Dagmara, Grzymisławski Marian, Dobrowolska Agnieszka, Kawka Edyta, Korybalska Katarzyna, Bręborowicz Andrzej, Witowski Janusz, Kanikowska Dominika
机构信息
Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Science, Poznan, Poland.
出版信息
Front Nutr. 2023 Feb 6;10:1078508. doi: 10.3389/fnut.2023.1078508. eCollection 2023.
INTRODUCTION
Physiological and biochemical processes in the human body occur in a specific order and show rhythmic variability. Time dependence characterizes the secretion of cortisol and dehydroepiandrosterone (DHEA). One-day fasting implies alternating fasting days and eating days. The study aimed to determine how 24-h fasting affects the daily rhythm of cortisol and DHEA levels in obese people while taking into account gender and chronotype.
METHODS
Forty-nine obese patients (BMI 32.2-67.1 kg/m; 25 women and 24 men) underwent a 3-week hospital-controlled calorie restriction diet to reduce body weight. During hospitalization, patients fasted for 1 day, during which only water could be consumed. Samples of whole mixed unstimulated saliva were collected at 2-3-h intervals over a 64-h period and analyzed for cortisol and DHEA by immunoassays. The individual chronotypes were assessed by the morning and evening questionnaire, according to Horne and Östberg. Three components of daily rhythm were evaluated: amplitude, acrophase, and the so-called MESOR.
RESULTS
Cortisol rhythm showed differences in amplitude ( = 0.0127) and acrophase ( = 0.0005). The amplitude on the fasting day was 11% higher ( = 0.224) than the day after. The acrophase advanced on the day of fasting, 48 min earlier than the day before ( = 0.0064), and by 39 min to the day after fasting ( = 0.0005). In the rhythm of DHEA, differences were found in the MESOR ( = 0.0381). The MESOR on the fasting day increased.
DISCUSSION
Our results obtained during 64 consecutive hours of saliva sampling suggest that one-day fasting may affect three components of cortisol and DHEA daily rhythm. Additionally, no differences were found in the daily rhythm between the morning and evening chronotypes and between females and males. Although aging did not influence daily cortisol rhythm, DHEA amplitude, MESOR, and acrophase changed with age. To the best of our knowledge, this is the first presentation of changes in DHEA rhythm during one-day fasting.
引言
人体中的生理和生化过程按特定顺序发生，并呈现出节律性变化。皮质醇和脱氢表雄酮（DHEA）的分泌具有时间依赖性。一日禁食意味着禁食日和进食日交替进行。本研究旨在确定24小时禁食如何影响肥胖人群皮质醇和DHEA水平的每日节律，同时考虑性别和昼夜节律类型。
方法
49名肥胖患者（BMI 32.2 - 67.1 kg/m；25名女性和24名男性）接受了为期3周的医院控制热量限制饮食以减轻体重。住院期间，患者禁食1天，在此期间只能饮水。在64小时内每隔2 - 3小时采集一次未刺激的全混合唾液样本，并通过免疫测定法分析皮质醇和DHEA。根据霍恩和奥斯特伯格的方法，通过早晚问卷评估个体的昼夜节律类型。评估了每日节律的三个组成部分：振幅、峰相位和所谓的中值。
结果
皮质醇节律在振幅（= 0.0127）和峰相位（= 0.0005）上存在差异。禁食日的振幅比禁食后一天高11%（= 0.224）。禁食日的峰相位提前，比前一天早48分钟（= 0.0064），比禁食后一天早39分钟（= 0.0005）。在DHEA节律中，中值存在差异（= 0.0381）。禁食日的中值增加。
讨论
我们在连续64小时唾液采样期间获得的结果表明，一日禁食可能会影响皮质醇和DHEA每日节律的三个组成部分。此外，在早晚昼夜节律类型之间以及男女之间的每日节律中未发现差异。虽然衰老不影响每日皮质醇节律，但DHEA的振幅、中值和峰相位随年龄变化。据我们所知，这是首次呈现一日禁食期间DHEA节律的变化。
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