Perkins Rachel S, Singh Rishika, Abell Amy N, Krum Susan A, Miranda-Carboni Gustavo A
Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, United States.
College of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States.
Front Cell Dev Biol. 2023 Feb 6;11:1120365. doi: 10.3389/fcell.2023.1120365. eCollection 2023.
WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate decisions. WNT10B plays roles in many tissues, including bone, adipocytes, skin, hair, muscle, placenta, and the immune system. Aberrant WNT10B signaling leads to several diseases, such as osteoporosis, obesity, split-hand/foot malformation (SHFM), fibrosis, dental anomalies, and cancer. We reviewed WNT10B a decade ago, and here we provide a comprehensive update to the field. Novel research on WNT10B has expanded to many more tissues and diseases. polymorphisms and mutations correlate with many phenotypes, including bone mineral density, obesity, pig litter size, dog elbow dysplasia, and cow body size. In addition, the field has focused on the regulation of using upstream mediators, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). We also discussed the therapeutic implications of WNT10B regulation. In summary, research conducted during 2012-2022 revealed several new, diverse functions in the role of WNT10B in physiology and disease.
WNT10B是分泌型糖蛋白WNT家族的成员之一，它激活WNT/β-连环蛋白信号级联反应，以控制细胞增殖、干性、多能性和细胞命运决定。WNT10B在许多组织中发挥作用，包括骨骼、脂肪细胞、皮肤、毛发、肌肉、胎盘和免疫系统。WNT10B信号异常会导致多种疾病，如骨质疏松症、肥胖症、手足裂畸形（SHFM）、纤维化、牙齿异常和癌症。我们在十年前对WNT10B进行了综述，在此我们为该领域提供全面的更新。关于WNT10B的新研究已扩展到更多的组织和疾病。多态性和突变与许多表型相关，包括骨密度、肥胖、猪的产仔数、犬肘关节发育不良和牛的体型。此外，该领域还聚焦于利用上游介质，如微小RNA（miRNA）和长链非编码RNA（lncRNA）对WNT10B的调控。我们还讨论了WNT10B调控的治疗意义。总之，2012年至2022年期间进行的研究揭示了WNT10B在生理和疾病中的几种新的、多样的功能。
