Ren Sihang, Lin Yuyang, Liu Wenyue, Yang Liqun, Zhao Muxin
Department of Plastic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, China.
Front Bioeng Biotechnol. 2023 Feb 6;11:1136453. doi: 10.3389/fbioe.2023.1136453. eCollection 2023.
Bone defect and repair is a common but difficult problem in restorative and reconstructive surgery. Bone tissue defects of different sizes caused by different reasons bring functional limitations and cosmetic deformities to patients. Mesenchymal stem cells (MSC), a major hotspot in the field of regeneration in recent years, have been widely used in various studies on bone tissue regeneration. Numerous studies have shown that the bone regenerative effects of MSC can be achieved through exosome-delivered messages. Although its osteogenic mechanism is still unclear, it is clear that MSC-Exos can directly or indirectly support the action of bone regeneration. It can act directly on various cells associated with osteogenesis, or by carrying substances that affect cellular activators or the local internal environment in target cells, or it can achieve activation of the osteogenic framework by binding to materials. Therefore, this review aims to summarize the types and content of effective contents of MSC-Exos in bone regeneration, as well as recent advances in the currently commonly used methods to enable the binding of MSC-Exos to the framework and to conclude that MSC-Exos is effective in promoting osteogenesis.
骨缺损与修复是修复重建外科中常见但棘手的问题。不同原因导致的不同大小的骨组织缺损给患者带来功能限制和外观畸形。间充质干细胞（MSC）是近年来再生领域的一个主要热点，已广泛应用于骨组织再生的各类研究中。大量研究表明，MSC的骨再生效应可通过外泌体传递信息来实现。尽管其成骨机制尚不清楚，但很明显MSC-Exos可直接或间接支持骨再生作用。它可直接作用于与成骨相关的各类细胞，或通过携带影响靶细胞中细胞激活剂或局部内部环境的物质，或通过与材料结合实现对成骨支架的激活。因此，本综述旨在总结MSC-Exos在骨再生中的有效成分类型和含量，以及目前常用的使MSC-Exos与支架结合的方法的最新进展，并得出MSC-Exos在促进成骨方面有效的结论。
