Li Jialing, Fan Zilu, Guan Zhenju, Ruan Jianping
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Nanchong Central Hospital (Nanchong Hospital of Beijing Anzhen Hospital,Capital Medical University), the Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, China.
Front Bioeng Biotechnol. 2024 Dec 11;12:1485437. doi: 10.3389/fbioe.2024.1485437. eCollection 2024.
Alveolar bone defects pose significant challenges in dentistry. Due to the complexity of alveolar bone anatomy and insufficient repair mechanisms, large bone defects are difficult for the body to heal naturally. Clinical treatment typically involves the use of bone substitute materials. However, current substitutes often suffer from limitations such as insufficient osteoinductivity, rapid degradation, inflammatory responses, and poor mechanical properties. Additionally, the irregular morphology of alveolar bone defects complicates the application of solid bone substitutes, potentially leading to secondary damage at the repair site.
To address these challenges, this study introduces an innovative approach by integrating MXene nanomaterials into Ag-HA/GelMA hydrogels to create an injectable MXene/Ag-HA composite hydrogel. MXene nanomaterials are renowned for their excellent biocompatibility, antibacterial properties, and mechanical strength.
The results indicate that the MXene/Ag-HA composite hydrogel exhibits satisfactory mechanical and biological properties. Specifically, it demonstrates excellent antibacterial, antioxidant, and osteogenic activities. Gene expression analysis further reveals that the MXene composite hydrogel promotes osteogenesis by regulating the expression of Dmp1 and Dusp1.
The findings of this study suggest that the MXene/Ag-HA composite hydrogel is a promising candidate for alveolar bone repair and regeneration. The integration of MXene nanomaterials into the hydrogel enhances its mechanical and biological properties, making it well-suited for the treatment of irregular alveolar bone defects. Furthermore, the study underscores the vast potential of MXene nanomaterials in the biomedical field, hinting at potential applications beyond alveolar bone repair.
牙槽骨缺损在牙科领域构成了重大挑战。由于牙槽骨解剖结构的复杂性以及修复机制不足，大面积骨缺损难以让身体自然愈合。临床治疗通常涉及使用骨替代材料。然而，目前的替代材料往往存在诸如骨诱导性不足、降解迅速、炎症反应以及机械性能差等局限性。此外，牙槽骨缺损的不规则形态使固体骨替代材料的应用变得复杂，可能导致修复部位的二次损伤。
为应对这些挑战，本研究引入了一种创新方法，即将MXene纳米材料整合到Ag-HA/GelMA水凝胶中，以制备可注射的MXene/Ag-HA复合水凝胶。MXene纳米材料以其优异的生物相容性、抗菌性能和机械强度而闻名。
结果表明，MXene/Ag-HA复合水凝胶具有令人满意的机械和生物学性能。具体而言，它表现出优异的抗菌、抗氧化和成骨活性。基因表达分析进一步揭示，MXene复合水凝胶通过调节Dmp1和Dusp1的表达来促进成骨作用。
本研究结果表明，MXene/Ag-HA复合水凝胶是牙槽骨修复和再生的一个有前景的候选材料。将MXene纳米材料整合到水凝胶中增强了其机械和生物学性能，使其非常适合治疗不规则的牙槽骨缺损。此外，该研究强调了MXene纳米材料在生物医学领域的巨大潜力，暗示了其在牙槽骨修复之外的潜在应用。
