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基质金属蛋白酶与骨肉瘤的全球科学趋势：文献计量与可视化分析

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis.

作者信息

Wu Xin, Ma Shiwei, Wu Zhongguang, Zhao Qiangqiang

机构信息

Department of Spine Surgery, Third Xiangya Hospital, Central South University, Changsha, China.

Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China.

出版信息

Front Oncol. 2023 Feb 6;13:1064815. doi: 10.3389/fonc.2023.1064815. eCollection 2023.

DOI:10.3389/fonc.2023.1064815
PMID:36814819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9939641/
Abstract

OBJECTIVE

This study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to the role of Metalloproteinase in osteosarcoma.

METHODS

945 Articles and reviews associated with the role of Metalloproteinase in osteosarcoma were obtained from the WoSCC and analyzed by Citespace and Vosviewer.

RESULTS

The main aspects of research on the role of MMP in OS are invasion and metastasis. The latest hotspots were found to be the mechanism of MMP promoting invasion and metastasis, lung metastasis, and antitumor activity. Notably, invasion, metastasis, and antitumor activity were potentially turning points in the MMP-OS field. In the future, the primary research hotspot in the field of MMP-OS may be to study the mechanism, explore their role in the OS lung metastasis, and determine their role in the cancer therapy process.

CONCLUSION

This study thus offers a comprehensive overview of the MMP-OS-related field using bibliometrics and visual methods, which will provide a valuable reference for researchers interested in the field of MMP-OS.

摘要

目的

本研究旨在确定作者、国家、机构和期刊之间的合作及其影响，评估知识基础，识别现有趋势，并揭示与金属蛋白酶在骨肉瘤中的作用相关的新兴主题。

方法

从科学网核心合集（WoSCC）获取了945篇与金属蛋白酶在骨肉瘤中的作用相关的文章和综述，并通过Citespace和Vosviewer进行分析。

结果

基质金属蛋白酶（MMP）在骨肉瘤（OS）中作用的研究主要方面是侵袭和转移。发现最新热点是MMP促进侵袭和转移的机制、肺转移和抗肿瘤活性。值得注意的是，侵袭、转移和抗肿瘤活性可能是MMP-OS领域的转折点。未来，MMP-OS领域的主要研究热点可能是研究其机制，探索它们在骨肉瘤肺转移中的作用，并确定它们在癌症治疗过程中的作用。

结论

因此，本研究使用文献计量学和可视化方法对MMP-OS相关领域进行了全面概述，这将为对MMP-OS领域感兴趣的研究人员提供有价值的参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/348d9d1ec07f/fonc-13-1064815-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/8731899f8597/fonc-13-1064815-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/a67c162ac5bb/fonc-13-1064815-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/e36d2cbcd571/fonc-13-1064815-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/53c2c938d829/fonc-13-1064815-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/c481a48ec336/fonc-13-1064815-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/4f0ad146d9ad/fonc-13-1064815-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/1fa7bf0955f8/fonc-13-1064815-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/1422f0e60281/fonc-13-1064815-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/348d9d1ec07f/fonc-13-1064815-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/8731899f8597/fonc-13-1064815-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/84d1cf858818/fonc-13-1064815-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/d549c06b21bd/fonc-13-1064815-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/711c04626181/fonc-13-1064815-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/3862b52beafb/fonc-13-1064815-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/a67c162ac5bb/fonc-13-1064815-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/825de61baecc/fonc-13-1064815-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/e36d2cbcd571/fonc-13-1064815-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/53c2c938d829/fonc-13-1064815-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/c481a48ec336/fonc-13-1064815-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/4f0ad146d9ad/fonc-13-1064815-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/1fa7bf0955f8/fonc-13-1064815-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/1422f0e60281/fonc-13-1064815-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd65/9939641/348d9d1ec07f/fonc-13-1064815-g014.jpg

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