铁催化的α-三氟甲基烯烃的烷基化反应：构建含 CF 和 N 基团的季碳立体中心的方法。
Fe-Catalyzed Alkylazidation of α-Trifluoromethylalkenes: An Access to Quaternary Stereocenters Containing CF and N Groups.
机构信息
Department of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
School of Chemistry and Chemical Engineering, Key Laboratory for Green Processing of Chemical Engineering of Xin-jiang Bingtuan, Shihezi University, Shihezi, Xinjiang 832003, China.
出版信息
Org Lett. 2023 Mar 3;25(8):1336-1341. doi: 10.1021/acs.orglett.3c00439. Epub 2023 Feb 23.
A concise Fe-catalyzed alkylazidation of α-trifluoromethylalkenes via a C-C bond cleavage/radical addition/azidation cascade is described. This protocol features a broad substrate scope, excellent functional group compatibility, and the ability to be performed on a gram scale, thus offering a practical and step-economic approach to the synthetically useful tertiary α-trifluoromethyl azides.
本文描述了一种通过 C-C 键断裂/自由基加成/叠氮化串联反应实现的α-三氟甲基烯烃的简洁铁催化烷基叠氮化反应。该方案具有广泛的底物范围、优异的官能团相容性以及能够在克级规模上进行的能力，因此为合成上有用的叔α-三氟甲基叠氮化物提供了一种实用且经济的方法。
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