Petersen R A, Friend S H, Albert D M
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
J Pediatr Ophthalmol Strabismus. 1987 Sep-Oct;24(5):247-8. doi: 10.3928/0191-3913-19870901-12.
A boy was discovered to have retinoblastoma in his right eye at age 29 months. The eye was enucleated and showed invasion of the choroid and optic nerve on examination. Bone marrow aspiration was negative in January 1981. Orbital recurrence was noted 1 month later and bone marrow aspiration was positive 2 months later. MAD-DOC chemotherapy and radiation therapy to the right orbit and brain were initiated immediately. The tumor has remained in remission since completion of the chemotherapy 18 months later. A preleukemic syndrome occurred in July 1984, and a successful bone marrow transplantation was performed in November 1984. He resumed normal growth and has remained well. Metastatic retinoblastoma should no longer be thought of as invariably fatal.
一名29个月大的男孩被发现右眼患有视网膜母细胞瘤。该眼被摘除，检查显示脉络膜和视神经受侵。1981年1月骨髓穿刺结果为阴性。1个月后发现眼眶复发，2个月后骨髓穿刺呈阳性。立即开始了MAD - DOC化疗以及对右侧眼眶和脑部的放射治疗。18个月后化疗结束，肿瘤一直处于缓解状态。1984年7月出现白血病前期综合征，1984年11月成功进行了骨髓移植。他恢复了正常生长且一直状况良好。转移性视网膜母细胞瘤不应再被认为必定是致命的。
