Aziz Md Abdul, Millat Md Shalahuddin, Akter Tahmina, Hossain Md Shahadat, Islam Md Monirul, Mohsin Shahriar, Ansari Farzana, Kabir Asma, Amin Mohammad Nurul, Islam Mohammad Safiqul
Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, 3814, Bangladesh.
Heliyon. 2023 Feb 4;9(2):e13493. doi: 10.1016/j.heliyon.2023.e13493. eCollection 2023 Feb.
Obesity has become a global health issue, more precisely, a pandemic throughout the present world due to its high prevalence in the recent era. Increased risk of morbidity and mortality in obese patients can be attributed to its association with the development of different life-threatening conditions. Plants are considered one of the most important sources of bioactive molecules which are used against a wide range of health disorders. This systematic review explores the efficacy as well as the safety profile of commonly used medicinal plants in the management of obesity that may help people to maintain a healthy weight.
This review is based on comprehensive literature searches from PubMed, Science Direct, Scopus, and Google Scholar databases using the keywords- "plants in obesity", "plants used in weight reduction" or keywords that are similar to those. Medicinal plants which have been clinically proven for their anti-obesity effect have only been selected for this study and attempts to investigate beneficial effects and adverse effects along with their mechanism of action have also been taken in this review.
A significant reduction of weight in both human and other animals are exhibited by the extracts of Phaseolus vulgaris, green coffee, Yerba Mate, green tea, Gynostemma pentaphyllum, and the combination of Cissus quadrangularis/Irvingia gabonensis. All of those plant extracts seemed to work on different physiological pathways and none of those extracts showed any notable adverse effects in human or animal models.
Our review suggests that the discussed medicinal plants are effective in reducing the weight of obese patients without causing notable adverse reactions. Although further study is necessary to confirm their exact molecular mechanism and safety in human use.
肥胖已成为一个全球性的健康问题，确切地说，由于其在当今世界的高患病率，肥胖已成为一场全球性的流行病。肥胖患者发病和死亡风险的增加可归因于其与多种危及生命的疾病发展相关。植物被认为是生物活性分子的最重要来源之一，这些生物活性分子可用于对抗多种健康疾病。本系统综述探讨了常用药用植物在肥胖管理中的疗效和安全性，这可能有助于人们维持健康体重。
本综述基于对PubMed、Science Direct、Scopus和谷歌学术数据库的全面文献检索，使用关键词“肥胖中的植物”、“用于减肥的植物”或与之类似的关键词。本研究仅选择了已在临床上证明具有抗肥胖作用的药用植物，并在本综述中试图研究其有益效果和不良反应及其作用机制。
菜豆、绿咖啡、马黛茶、绿茶、绞股蓝以及四角金虎尾/加蓬腰果树提取物在人类和其他动物中均显著减轻了体重。所有这些植物提取物似乎作用于不同的生理途径，并且在人类或动物模型中，这些提取物均未显示出任何明显的不良反应。
我们的综述表明，所讨论的药用植物在减轻肥胖患者体重方面有效，且不会引起明显的不良反应。尽管需要进一步研究以确认它们在人类使用中的确切分子机制和安全性。
