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Mean residence time in peripheral tissue.

作者信息

McNamara P J, Fleishaker J C, Hayden T L

机构信息

Division of Pharmaceutics and Pharmaceutical Analysis, College of Pharmacy, University of Kentucky, Lexington 40536.

出版信息

J Pharmacokinet Biopharm. 1987 Aug;15(4):439-50. doi: 10.1007/BF01066523.

Abstract

The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.

摘要

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