McNamara P J, Fleishaker J C, Hayden T L
Division of Pharmaceutics and Pharmaceutical Analysis, College of Pharmacy, University of Kentucky, Lexington 40536.
J Pharmacokinet Biopharm. 1987 Aug;15(4):439-50. doi: 10.1007/BF01066523.
The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.