外周组织中的平均驻留时间：一个用于评估药物组织分布的线性处置参数。 - Suppr

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超能文献

Mean residence time in peripheral tissue: a linear disposition parameter useful for evaluating a drug's tissue distribution.

作者信息

Veng-Pedersen P, Gillespie W

出版信息

J Pharmacokinet Biopharm. 1984 Oct;12(5):535-43. doi: 10.1007/BF01060131.

DOI:10.1007/BF01060131

PMID:6520747

Abstract

摘要

相似文献

Mean residence time in peripheral tissue: a linear disposition parameter useful for evaluating a drug's tissue distribution.外周组织中的平均驻留时间：一个用于评估药物组织分布的线性处置参数。

J Pharmacokinet Biopharm. 1984 Oct;12(5):535-43. doi: 10.1007/BF01060131.

Single pass mean residence time in peripheral tissues: a distribution parameter intrinsic to the tissue affinity of a drug.药物在外周组织中的单次通过平均驻留时间：一个反映药物组织亲和力的内在分布参数。

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A method for evaluating the mean residence times of metabolites in the body, systemic circulation, and the peripheral tissue not requiring separate i.v. administration of metabolite.一种评估代谢物在体内、体循环和外周组织中的平均驻留时间的方法，该方法无需单独静脉注射代谢物。

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Mean residence times and distribution volumes for drugs undergoing linear reversible metabolism and tissue distribution and linear or nonlinear elimination from the central compartments.经历线性可逆代谢、组织分布以及从中枢室进行线性或非线性消除的药物的平均驻留时间和分布容积。

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Importance of tissue distribution in determining drug disposition curves.组织分布在确定药物处置曲线中的重要性。

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Pharmacokinetics: dose-dependent changes.药代动力学：剂量依赖性变化。

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Mean residence time of drugs administered non-instantaneously and undergoing linear tissue distribution and reversible metabolism and linear or non-linear elimination from the central compartment.

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Quantitative structure-pharmacokinetic relationships and drug design.定量构效关系与药物设计。

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Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. II. Clearance concepts applied to the evaluation of distribution kinetics.线性及某些非线性药物处置的模型无关消除/分布函数分解的定理及推论。II. 应用于分布动力学评估的清除概念。

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The determination of mean residence time using statistical moments: it is correct.

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Mean residence time in peripheral tissue.

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Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. III. Peripheral bioavailability and distribution time concepts applied to the evaluation of distribution kinetics.线性及某些非线性药物处置的模型无关消除/分布函数分解的定理与推论。III. 应用于分布动力学评估的外周生物利用度和分布时间概念

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General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment.具有从任何隔室消除的线性乳突模型中平均停留时间、清除率和容积参数的一般处理。

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本文引用的文献

The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time.统计矩理论在体内溶出时间和吸收时间评估中的应用。

J Pharmacokinet Biopharm. 1980 Oct;8(5):509-34. doi: 10.1007/BF01059549.

Noncompartmental determination of the steady-state volume of distribution for any mode of administration.非房室模型法测定任何给药方式下的稳态分布容积。

J Pharm Sci. 1982 Mar;71(3):372-3. doi: 10.1002/jps.2600710332.

Acceleration of the body clearance of phenobarbital by oral activated charcoal.口服活性炭加速苯巴比妥的体内清除率。

N Engl J Med. 1982 Sep 9;307(11):642-4. doi: 10.1056/NEJM198209093071102.

Computation of model-independent pharmacokinetic parameters during multiple dosing.

J Pharm Sci. 1984 Apr;73(4):570-1. doi: 10.1002/jps.2600730436.

Pharmacokinetics of intravenous theophylline.静脉注射氨茶碱的药代动力学

Clin Pharmacol Ther. 1973 Jul-Aug;14(4):509-13. doi: 10.1002/cpt1973144part1509.

The pharmacokinetics of propylthiouracil.丙硫氧嘧啶的药代动力学。

Acta Pharmacol Toxicol (Copenh). 1974 Nov;35(5):361-9. doi: 10.1111/j.1600-0773.1974.tb00756.x.

Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

J Pharmacokinet Biopharm. 1975 Jun;3(3):181-92. doi: 10.1007/BF01067907.

Pharmocokinetics of hexobarbital in man after intravenous infusion.

J Pharmacokinet Biopharm. 1975 Feb;3(1):1-11. doi: 10.1007/BF01066591.

Statistical moments in pharmacokinetics.药代动力学中的统计矩

J Pharmacokinet Biopharm. 1978 Dec;6(6):547-58. doi: 10.1007/BF01062109.

Theory of the mean absorption time, an adjunct to conventional bioavailability studies.平均吸收时间理论，传统生物利用度研究的辅助手段。

J Pharm Pharmacol. 1978 Aug;30(8):476-8. doi: 10.1111/j.2042-7158.1978.tb13296.x.

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