Wang Ji, Gong Zhengpeng, Yu Ming
Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.
Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang, China.
Front Oncol. 2023 Feb 3;13:942777. doi: 10.3389/fonc.2023.942777. eCollection 2023.
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor with a significant mortality rate, especially in patients at locally advanced stage, or with recurrence and metastasis. Immunotherapy has shown remarkable breakthrough in the treatment of locally advanced cancer, recurrence and metastasis in recent years. During this time, a large number of HNSCC immunotherapy studies have been published. However, few studies employed bibliometric analysis. This work analyzes HNSCC immunotherapy trends and hotspots using bibliometric analysis to get better understanding of the current state and future direction of HNSCC immunotherapy.
Relevant articles and publications about immunotherapy of HNSCC were extracted from Web of Science Core Collection (WoSCC). Bibliometrics was used to study these publications in terms of countries/regions, institutions, authors (cited authors), journals (cited journals), references, and keywords, so as to identify research hotspots and to predict future research trends in this field.
A total of 1377 English articles published between 2000 and 2022 were collected. It is found that the number of articles increases rapidly from 2016. The United States has the largest number of publications (n=538), followed by China (n=407) and Germany (n=175). The institute with the highest published papers is the University of Pittsburgh (n=67). In terms of author, Robert L Ferris ranks first among the top ten cited authors. Oral Oncology (impact factor (IF) (2021) = 5.972) is the most prolific academic journal in immunotherapy of HNSCC. According to the reference cluster analysis, the research hot topic has shifted from basic research on immunotherapy of head and neck cancer to the study of prognosis. Keywords analysis also reveals that the study of patients' prognoses is at the core of immunotherapy for HNSCC.
Currently, head and neck cancer research focus primarily on prognostic significance, cancer treatment, and poor prognosis. However, the researches on immunotherapy for head and neck malignancies is the growing trend in near future. Notably, United States has made significant contributions to this field.
头颈部鳞状细胞癌（HNSCC）是一种常见的恶性肿瘤，死亡率很高，特别是局部晚期、复发或转移的患者。近年来，免疫疗法在局部晚期癌症、复发和转移的治疗中取得了显著突破。在此期间，发表了大量关于HNSCC免疫疗法的研究。然而，很少有研究采用文献计量分析。本研究采用文献计量分析方法分析HNSCC免疫疗法的趋势和热点，以更好地了解HNSCC免疫疗法的现状和未来方向。
从Web of Science核心合集（WoSCC）中提取有关HNSCC免疫疗法的相关文章和出版物。运用文献计量学方法，从国家/地区、机构、作者（被引作者）、期刊（被引期刊）、参考文献和关键词等方面对这些出版物进行研究，以确定研究热点并预测该领域未来的研究趋势。
共收集了2000年至2022年间发表的1377篇英文文章。发现文章数量自2016年起迅速增加。美国的出版物数量最多（n = 538），其次是中国（n = 407）和德国（n = 175）。发表论文最多的机构是匹兹堡大学（n = 67）。在作者方面，罗伯特·L·费里斯在十大被引作者中排名第一。《口腔肿瘤学》（2021年影响因子（IF）= 5.972）是HNSCC免疫疗法领域发文量最多的学术期刊。根据参考文献聚类分析，研究热点已从头颈癌免疫疗法的基础研究转向预后研究。关键词分析还表明，患者预后研究是HNSCC免疫疗法的核心。
目前，头颈癌研究主要集中在预后意义、癌症治疗和预后不良方面。然而，头颈恶性肿瘤免疫疗法的研究在不久的将来呈增长趋势。值得注意的是，美国在该领域做出了重大贡献。
