Jiang Wei, Wang Zehui, Zhang Jun, Li Minghui
Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Cent Eur J Immunol. 2022;47(4):362-372. doi: 10.5114/ceji.2022.124416. Epub 2023 Jan 31.
Interleukin 25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and an important regulator of the type 2 immune response. Accumulating evidence suggests that IL-25 interacts with diverse immune as well as non-immune cells and plays a rather complicated role in different backgrounds of multiple organs. IL-25 has been studied in the physiology and pathology of the intestine to some extent. With epithelial cells being an important source in the intestine, IL-25 plays a key role in intestinal immune responses and is associated with inappropriate allergic reactions, autoimmune diseases, and cancer tumorigenesis. In this review, we discuss the emerging comprehension of the biology of IL-25, as well as its cellular sources, targets, and signaling transduction. In particular, we discuss how IL-25 participates in the development of intestinal diseases including helminth infection, inflammatory bowel diseases, food allergy and colorectal cancer, as well as its underlying role in future therapy.
白细胞介素25（IL-25），也称为IL-17E，是IL-17细胞因子家族的成员，也是2型免疫反应的重要调节因子。越来越多的证据表明，IL-25与多种免疫细胞和非免疫细胞相互作用，在多个器官的不同背景中发挥相当复杂的作用。IL-25已在肠道生理学和病理学方面得到了一定程度的研究。上皮细胞是肠道中IL-25的重要来源，它在肠道免疫反应中起关键作用，并与不适当的过敏反应、自身免疫性疾病和癌症肿瘤发生有关。在本综述中，我们讨论了对IL-25生物学的新认识，以及它的细胞来源、靶点和信号转导。特别是，我们讨论了IL-25如何参与肠道疾病的发展，包括蠕虫感染、炎症性肠病、食物过敏和结直肠癌，以及它在未来治疗中的潜在作用。
