Otomi Yoichi, Shinya Takayoshi, Kasai Hiroto, Okada Naoko, Matsushita Tomoki, Higashi Kohei, Matsuzaki Saya, Hiroshima Yuka, Kubo Michiko, Otsuka Hideki, Harada Masafumi
Tokushima University Hospital, Department of Radiology, Tokushima, Japan.
Tokushima Prefectural Central Hospital, Department of Radiology, Tokushima, Japan.
Mol Imaging Radionucl Ther. 2023 Feb 23;32(1):13-19. doi: 10.4274/mirt.galenos.2022.27136.
To compare vaccinated-side axillary lymph node uptake on F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) after coronavirus disease-2019 (COVID-19) and influenza vaccination.
We retrospectively analyzed 177 patients who underwent F-FDG PET/CT after COVID-19 or influenza vaccination. We compared the uptake of the vaccinated-side axillary lymph nodes of 109 COVID-19 vaccinated patients with those of a lot of influenza-vaccinated patients. We also compared the uptake between 66 patients who received the first COVID-19 vaccination with 43 who received the second COVID-19 vaccination.
F-FDG-avid axillary lymph nodes on the vaccinated side were significantly more frequently observed in the COVID-19 group (45%) than in the influenza group (19%) (p<0.001). When the interval between vaccination to PET/CT was within 7 days, there was no significant difference in the frequency of F-FDG-avid vaccinated-side axillary lymph nodes between the groups (COVID-19 group: 41% vs. influenza group: 45%, p=0.724). When the interval was over 7 days, F-FDG-avid lymph nodes were much more frequent in the COVID-19 group (47%) than in the influenza group (7%) (p<0.001). Comparing the first and second COVID-19 groups, F-FDG-avid lymph nodes were more frequent in the second vaccination group than in the first vaccination group, but the difference was not significant.
F-FDG-avid vaccinated-side axillary lymph nodes were more frequently observed in the COVID-19 group than in the influenza group. In the case of the COVID-19 vaccine, a delay of F-FDG PET/CT examination is recommended by a longer interval from vaccination than in the influenza vaccine.
比较2019冠状病毒病（COVID-19）疫苗和流感疫苗接种后，接种侧腋窝淋巴结在氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）上的摄取情况。
我们回顾性分析了177例在COVID-19或流感疫苗接种后接受F-FDG PET/CT检查的患者。我们将109例接种COVID-19疫苗患者的接种侧腋窝淋巴结摄取情况与大量接种流感疫苗患者的情况进行了比较。我们还比较了66例接受首次COVID-19疫苗接种的患者和43例接受第二次COVID-19疫苗接种的患者之间的摄取情况。
COVID-19组接种侧FDG摄取阳性的腋窝淋巴结显著多于流感组（45%对19%）（p<0.001）。当接种至PET/CT的间隔在7天内时，两组间接种侧FDG摄取阳性腋窝淋巴结的频率无显著差异（COVID-19组：41%对流感组：45%，p=0.724）。当间隔超过7天时，COVID-19组FDG摄取阳性淋巴结的频率显著高于流感组（47%对7%）（p<0.001）。比较首次和第二次COVID-19疫苗接种组，第二次接种组FDG摄取阳性淋巴结的频率高于首次接种组，但差异不显著。
COVID-19组接种侧FDG摄取阳性的腋窝淋巴结比流感组更常见。对于COVID-19疫苗，建议FDG PET/CT检查的延迟时间比流感疫苗接种后间隔更长。
