Małyszczak Artur, Żyto Magdalena, Przeździecka-Dołyk Joanna, Misiuk-Hojło Marta
Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Dolnoslaskie, Poland.
Department of Optics and Photonics, Wroclaw University of Science and Technology, Wroclaw, Dolnoslaskie, Poland.
Clin Ophthalmol. 2023 Feb 11;17:561-570. doi: 10.2147/OPTH.S389963. eCollection 2023.
The purpose of this study is to determine the relationships between foveal avascular zone (FAZ), foveal vascular density (FD) and GCC (ganglion cell complex) parameters in a healthy myopic population using optical coherence tomography angiography (angio-OCT).
Three hundred and eighty-one eyes of 381 healthy participants were included into this study and assigned to three groups according to their spherical equivalent (SE) values and an additional progressive myopia group. One randomly chosen eye from each patient was analyzed. GCC mean thickness, focal loss of volume (FLV), global loss of volume (GLV), FAZ area, FAZ perimeter, and FD parameters were obtained with the RTVue AngioOCT device.
FAZ area and its perimeter were strongly correlated with the belonging spherical equivalent group (p = 0.0001, p = 0.0008 accordingly), being the largest in progressive myopia subgroup (mean size 0.42mm). Other factors that were significantly higher in myopic eyes were FLV (p = 0.0023), GLV (p = 0.0020). There were no differences in FD between groups. In the myopic and progressive myopia groups, there was a significant relationship between FAZ area and FLV, GLV, and GCC thickness. We found that in myopic eyes with AXL exceeding 26.6 mm, FAZ becomes negatively correlated to mean GCC thickness.
In myopia, compared to non-myopic groups, there is a greater loss of neural tissue represented by a thinner GCC layer, greater FLV and GLV parameters, and worse blood supply represented by a larger FAZ area. Eye axial length of 26.6 mm is a breaking point, where the negative FAZ area to GCC thickness relationship curve is getting significantly steeper.
本研究旨在利用光学相干断层扫描血管造影术（血管OCT）确定健康近视人群中黄斑无血管区（FAZ）、黄斑血管密度（FD）与神经节细胞复合体（GCC）参数之间的关系。
本研究纳入了381名健康参与者的381只眼睛，并根据其等效球镜（SE）值分为三组以及一个额外的进行性近视组。从每位患者中随机选择一只眼睛进行分析。使用RTVue AngioOCT设备获取GCC平均厚度、局部体积损失（FLV）、整体体积损失（GLV）、FAZ面积、FAZ周长和FD参数。
FAZ面积及其周长与所属等效球镜组密切相关（相应地，p = 0.0001，p = 0.0008），在进行性近视亚组中最大（平均大小0.42mm）。近视眼中其他显著更高的因素是FLV（p = 0.0023）、GLV（p = 0.0020）。各组之间的FD没有差异。在近视组和进行性近视组中，FAZ面积与FLV、GLV和GCC厚度之间存在显著关系。我们发现，在眼轴长度超过26.6mm的近视眼中，FAZ与GCC平均厚度呈负相关。
在近视眼中，与非近视组相比，以较薄的GCC层为代表的神经组织损失更大，FLV和GLV参数更高，以更大的FAZ面积为代表的血液供应更差。眼轴长度26.6mm是一个转折点，此时FAZ面积与GCC厚度的负相关关系曲线变得明显更陡。
