Department of Ophthalmology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Department of Ophthalmology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2021 Nov;259(11):3221-3227. doi: 10.1007/s00417-021-05216-x. Epub 2021 May 7.
This study aims to investigate the early characteristics of retinochoroidal and peripapillary perfusion in non-pathological high myopia (HM) without retinopathy and compare them to the age- and sex-matched healthy subjects using optical coherence tomography angiography (OCTA).
This prospective, cross-sectional study included 35 eyes of 35 patients in the non-pathological HM group (axial length (AL) ≥ 26 mm) and 35 eyes of 35 subjects in the control group. OCT and OCTA were used for the assessment of vessel density, foveal avascular zone, subfoveal choroidal thickness, choriocapillaris flow area, retinal nerve fiber layer thickness, and optic nerve head measurements.
The VDs of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were significantly reduced in the HM group (47.9 ± 3.8%; 47.3 ± 6.6%) compared to the control group (50.8 ± 2.6%; 54.1 ± 4.8%) (p < 0.001). The whole vessel density (wpVD) (53.7 ± 2.7% vs. 56.2 ± 2.2%) and peripapillary VD (ppVD) (56.4% (range, 45.8-60.4%) vs. 58.4% (range, 52.6-62.3%)) values were significantly lower in the HM group (p < 0.005). The inside disc vessel density (iVD) was similar in both groups (62 ± 3.3% vs. 61.4 ± 2.7%) (p = 0.511).
The vessel densities (VDs) of SCP and DCP, wpVD, and ppVD were lower in the non-pathological HM group, but the iVD value was similar in both groups. This suggests that the main cause of VD reduction is more likely related to globe elongation rather than reduced oxygen and nutrients due to the thinning of the posterior pole (retina, sclera, and choroid). CLINICALTRIALS.
NCT04631991, 11/11/2020.
本研究旨在使用光相干断层扫描血管造影术（OCTA）研究非病理性高度近视（HM）患者（眼轴（AL）≥26mm）的视网膜脉络膜和视盘周围灌注的早期特征，并与年龄和性别匹配的健康对照组进行比较。
这是一项前瞻性、横断面研究，纳入 35 例非病理性 HM 组（35 只眼）和 35 例对照组（35 只眼）患者。采用 OCT 和 OCTA 评估血管密度、黄斑中心无血管区、中心凹下脉络膜厚度、脉络膜毛细血管血流面积、视网膜神经纤维层厚度和视盘头部测量值。
与对照组相比（50.8±2.6%；54.1±4.8%），HM 组（47.9±3.8%；47.3±6.6%）浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的血管密度（VD）明显降低（p<0.001）。全血管密度（wpVD）（53.7±2.7%比 56.2±2.2%）和视盘周围血管密度（ppVD）（56.4%（范围，45.8-60.4%）比 58.4%（范围，52.6-62.3%））值明显较低（p<0.005）。两组间内盘血管密度（iVD）相似（62±3.3%比 61.4±2.7%）（p=0.511）。
SCP 和 DCP、wpVD 和 ppVD 的血管密度（VD）在非病理性 HM 组中较低，但两组间 iVD 值相似。这表明，VD 降低的主要原因可能与眼球伸长有关，而不是由于后极（视网膜、巩膜和脉络膜）变薄导致氧气和营养物质减少。临床试验。
NCT04631991，2020 年 11 月 11 日。
