葡萄胎：部分性和完全性葡萄胎中的亲代染色体畸变。
Hydatidiform mole: parental chromosome aberrations in partial and complete moles.
作者信息
Vejerslev L O, Fisher R A, Surti U, Wake N
机构信息
Department of Medical Genetics, John F. Kennedy Institute, Glostrup/Copenhagen, Denmark.
出版信息
J Med Genet. 1987 Oct;24(10):613-5. doi: 10.1136/jmg.24.10.613.
The relationship between parental constitutional chromosome abnormalities and the development of hydatidiform mole was evaluated in series from four institutions. Karyotype analysis was performed on blood samples from 237 patients with a pathological diagnosis of complete mole and 217 of their spouses. One patient was found to have a constitutional balanced translocation, t(11;18), while one spouse was found to have a balanced translocation, t(4;20). Among 125 patients with partial mole and 106 of their spouses, one male was found to be a translocation carrier, t(13;14). No significant increase in the frequency of translocations in the parents of complete moles was found in any of the series considered separately or together. Data from the combined series show no evidence of constitutional parental chromosome aberrations as an aetiological factor in the development of molar pregnancies.
对来自四个机构的一系列病例进行了评估，以研究亲代染色体结构异常与葡萄胎发生之间的关系。对237例经病理诊断为完全性葡萄胎患者及其217名配偶的血液样本进行了核型分析。发现1例患者存在染色体结构平衡易位，核型为t(11;18)，1例配偶存在平衡易位，核型为t(4;20)。在125例部分性葡萄胎患者及其106名配偶中，发现1名男性为易位携带者，核型为t(13;14)。单独或合并考虑任何一个系列时，均未发现完全性葡萄胎患者父母的易位频率有显著增加。综合系列的数据显示，没有证据表明亲代染色体结构畸变是葡萄胎妊娠发生的病因学因素。
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