Xiao Pei, Cheng Hong, Wang Liange, Hou Dongqing, Li Haibo, Zhao Xiaoyuan, Xie Xianghui, Mi Jie
Center for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Front Nutr. 2023 Feb 3;10:1081896. doi: 10.3389/fnut.2023.1081896. eCollection 2023.
To investigate how serum 25-hydroxyvitamin D (25[OH]D) affects height growth velocity and the risk of low bone mineral density (BMD) in children.
A population-based prospective cohort study.
A total of 10 450 participants with complete follow-up records from a cohort were included in the current study. Serum 25(OH)D concentrations were measured at baseline and 2-year follow-up, and the average of 2-time measurements was used for analysis. Low BMD was defined as calcaneus speed of sound Z-score ≤ -1. The associations of vitamin D with height growth velocity and the risks of incident low BMD were evaluated using adjusted β and risk ratio ().
After multivariable adjustment, an inverse L-shaped association between serum 25(OH)D concentrations and height growth velocity was observed, leveling off up to 40-60 nmol/L. Overall, each 10 nmol/L higher serum 25(OH)D concentration was associated with a 0.15 cm/year higher height growth velocity ( < 0.001) and a 7% decreased risk of low BMD [ (95%): 0.93 (0.870.98)]. Compared to those with vitamin D deficiency, participants who had sufficient vitamin D had a 22% lower risk for low BMD [(95%): 0.78 (0.620.98)]. However, no significant associations between vitamin D and the risk of low BMD were found in overweight and obese children.
These findings highlight the importance of maintenance of sufficient 25(OH)D concentrations and healthy body weight during childhood in height growth and bone health promotion.
探讨血清25-羟维生素D（25[OH]D）如何影响儿童身高增长速度及低骨密度（BMD）风险。
基于人群的前瞻性队列研究。
本研究纳入了队列中10450名有完整随访记录的参与者。在基线和2年随访时测量血清25(OH)D浓度，并将2次测量的平均值用于分析。低BMD定义为跟骨声速Z评分≤ -1。使用调整后的β和风险比评估维生素D与身高增长速度以及低BMD发生风险之间的关联。
经过多变量调整后，观察到血清25(OH)D浓度与身高增长速度之间呈倒L形关联，在40 - 60 nmol/L时趋于平稳。总体而言，血清25(OH)D浓度每升高10 nmol/L，身高增长速度每年加快0.15 cm（P < 0.001），低BMD风险降低7% [风险比（95%置信区间）：0.93（0.870.98）]。与维生素D缺乏者相比，维生素D充足的参与者低BMD风险降低22% [风险比（95%置信区间）：0.78（0.620.98）]。然而，在超重和肥胖儿童中未发现维生素D与低BMD风险之间存在显著关联。
这些发现凸显了儿童期维持足够的25(OH)D浓度和健康体重对身高增长和骨骼健康促进的重要性。
