The State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
Int J Mol Sci. 2022 Aug 19;23(16):9338. doi: 10.3390/ijms23169338.
Body fat distribution is a well-established predictor of adverse medical outcomes, independent of overall adiposity. Studying body fat distribution sheds insights into the causes of obesity and provides valuable information about the development of various comorbidities. Compared to total adiposity, body fat distribution is more closely associated with risks of cardiovascular diseases. The present review specifically focuses on the sexual dimorphism in body fat distribution, the biological clues, as well as the genetic traits that are distinct from overall obesity. Understanding the sex determinations on body fat distribution and adiposity will aid in the improvement of the prevention and treatment of cardiovascular diseases (CVD).
体脂分布是不良医学结局的一个既定预测因子，独立于总体肥胖。研究体脂分布可以深入了解肥胖的原因，并提供有关各种合并症发展的有价值信息。与总体肥胖相比，体脂分布与心血管疾病风险的关联更为密切。本综述特别关注体脂分布的性别二态性、生物学线索以及与总体肥胖不同的遗传特征。了解体脂分布和肥胖的性别决定因素将有助于改善心血管疾病 (CVD) 的预防和治疗。
