Lahti Katri, Setänen Sirkku, Vorobyev Victor, Nyman Anna, Haataja Leena, Parkkola Riitta
Department of Pediatric Neurology, University of Turku and Turku University Hospital, PO Box 52, FI-20521, Turku, Finland.
Department of Adolescent Psychiatry, University of Turku and Turku University Hospital, Kunnallissairaalantie 20, rak4, 3.krs PL52, 20520 Turku, Finland.
Brain Commun. 2023 Feb 7;5(1):fcad009. doi: 10.1093/braincomms/fcad009. eCollection 2023.
Adolescents born very preterm have an increased risk for anxiety, social difficulties and inattentiveness, i.e. the 'preterm behavioural phenotype'. The extreme end of these traits comprises the core diagnostic features of attention and hyperactivity disorders and autism spectrum disorder, which have been reported to show aberrant dynamic resting-state functional network connectivity. This study aimed to compare this dynamism between adolescents born very preterm and controls. A resting-state functional magnetic resonance imaging was performed on 24 adolescents born very preterm (gestational age <32 weeks and/or birth weight ≤1500 g) and 32 controls born full term (≥37 weeks of gestation) at 13 years of age. Group-wise comparisons of dynamic connectivity between the resting-state networks were performed using both hard clustering and meta-state analysis of functional network connectivity. The very preterm group yielded a higher fraction of time spent in the least active connectivity state in hard clustering state functional network connectivity, even though no group differences in pairwise connectivity patterns were discovered. The meta-state analysis showed a decreased fluidity and dynamic range in the very preterm group compared with controls. Our results suggest that the 13-year-old adolescents born very preterm differ from controls in the temporal characteristics of functional connectivity. The findings may reflect the long-lasting effects of prematurity and the clinically acknowledged 'preterm behavioural phenotype'.
极早早产出生的青少年出现焦虑、社交困难和注意力不集中等问题的风险增加，即“早产行为表型”。这些特征的极端情况包括注意力缺陷多动障碍和自闭症谱系障碍的核心诊断特征，据报道这些疾病表现出异常的动态静息态功能网络连接。本研究旨在比较极早早产出生的青少年与对照组之间的这种动态变化。对24名极早早产出生的青少年（胎龄<32周和/或出生体重≤1500克）和32名足月出生（≥37周妊娠）的13岁青少年进行了静息态功能磁共振成像检查。使用功能网络连接的硬聚类和元状态分析对静息态网络之间的动态连接进行组间比较。尽管在成对连接模式上未发现组间差异，但在硬聚类状态功能网络连接中，极早早产组处于最不活跃连接状态的时间比例更高。元状态分析显示，与对照组相比，极早早产组的流动性和动态范围降低。我们的结果表明，极早早产出生的13岁青少年在功能连接的时间特征上与对照组不同。这些发现可能反映了早产的长期影响以及临床上公认的“早产行为表型”。
